STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
nadDNicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (230 aa)    
Predicted Functional Partners:
nadE
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family.
 
 
 0.988
Arch_1116
Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.
 
 
 0.980
Arch_0646
CinA domain protein; COGs: COG1546 Uncharacterized protein (competence- and mitomycin-induced); InterPro IPR008136; KEGG: kse:Ksed_17980 competence/damage-inducible protein CinA; PFAM: CinA domain protein; SPTR: A7BD51 Putative uncharacterized protein; PFAM: Competence-damaged protein; TIGRFAM: competence/damage-inducible protein CinA C-terminal domain; Belongs to the CinA family.
 
 
 0.950
nadK
ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
 
 
 0.944
rsfS
Iojap-like protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
 
  
 0.918
Arch_0994
COGs: COG3288 NAD/NADP transhydrogenase alpha subunit; InterProIPR016040:IPR004571:IPR008143:IPR007886:IPR 007698; KEGG: cur:cur_1513 NAD(P) transhydrogenase subunit alpha; PFAM: alanine dehydrogenase/PNT domain protein; SPTR: D0WN83 NAD(P)(+) transhydrogenase, alpha subunit; TIGRFAM: NAD(P) transhydrogenase, alpha subunit; PFAM: Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase/PNT, N-terminal domain; TIGRFAM: NAD(P) transhydrogenase, alpha subunit.
     
 0.905
Arch_0392
NUDIX hydrolase; COGs: COG2816 NTP pyrophosphohydrolase containing a Zn-finger probably nucleic-acid-binding; InterPro IPR000086:IPR020084:IPR015376:IPR015797; KEGG: nca:Noca_1514 NUDIX hydrolase; PFAM: NUDIX hydrolase; Zinc ribbon NADH pyrophosphatase; SPTR: D1BAV9 Zn-finger containing NTP pyrophosphohydrolase; PFAM: NUDIX domain.
     
 0.903
Arch_0239
LPXTG-motif cell wall anchor domain protein; COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR004843:IPR008334:IPR019931:IPR006179; KEGG: cgt:cgR_0412 hypothetical protein; PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; SPTR: D0WQ91 5-nucleotidase; TIGRFAM: LPXTG-motif cell wall anchor domain protein; PFAM: 5'-nucleotidase, C-terminal domain; TIGRFAM: LPXTG-motif cell wall anchor domain.
   
 
  0.901
Arch_0025
5'-Nucleotidase domain protein; COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR008334:IPR006179; KEGG: mxa:MXAN_5361 putative 5'-nucleotidase; PFAM: 5'-Nucleotidase domain protein; SPTR: A8TK86 5'-Nucleotidase; PFAM: 5'-nucleotidase, C-terminal domain; Belongs to the 5'-nucleotidase family.
     
  0.900
Arch_0203
LPXTG-motif cell wall anchor domain protein; COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR004843:IPR008334:IPR019931:IPR006179; KEGG: cjk:jk1044 putative 5'-nucleotidase family protein; PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; SPTR: Q4JVE9 Putative 5'-nucleotidase family protein; TIGRFAM: LPXTG-motif cell wall anchor domain protein; PFAM: Calcineurin-like phosphoesterase; 5'-nucleotidase, C-terminal domain; TIGRFAM: LPXTG-motif cell wall anchor domain; Belongs to the 5'-nucleotidase family.
     
  0.900
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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