STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
Arch_1079formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (284 aa)    
Predicted Functional Partners:
rnc
Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
     
 0.870
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.867
Arch_1081
Protein of unknown function DUF177; COGs: COG1399 metal-binding possibly nucleic acid-binding protein; InterPro IPR003772; KEGG: jde:Jden_1668 protein of unknown function DUF177; PFAM: protein of unknown function DUF177; SPTR: D0WNC6 Putative uncharacterized protein; PFAM: Uncharacterized ACR, COG1399.
     
 0.859
coaE
dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
 
  
 0.841
Arch_0750
COGs: COG2176 DNA polymerase III alpha subunit (gram-positive type); InterProIPR012337:IPR000305:IPR006055:IPR006054:IPR 013520; KEGG: bcv:Bcav_1900 DNA polymerase III, epsilon subunit; PFAM: Exonuclease RNase T and DNA polymerase III; Excinuclease ABC C subunit domain protein; PRIAM: DNA-directed DNA polymerase; SMART: Exonuclease; Excinuclease ABC C subunit domain protein; SPTR: D0WQL3 Putative DNA polymerase III, epsilon subunit; TIGRFAM: DNA polymerase III, epsilon subunit; PFAM: Exonuclease; GIY-YIG catalytic domain; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family.
  
  
 0.822
Arch_1085
DEAD/DEAH box helicase domain protein; COGs: COG1200 RecG-like helicase; InterProIPR016027:IPR014021:IPR001650:IPR014001:IPR 004365:IPR011545; KEGG: xce:Xcel_2279 ATP-dependent DNA helicase RecG; PFAM: DEAD/DEAH box helicase domain protein; nucleic acid binding OB-fold tRNA/helicase-type; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein; SPTR: D0WND1 Putative ATP-dependent DNA helicase RecG; PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase; OB-fold nucleic acid binding domain; TIGRFAM: ATP-dependent DNA helicase RecG.
     
 0.773
coaD
Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.
  
  
 0.767
Arch_1078
Two component transcriptional regulator, LuxR family; COGs: COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; InterPro IPR011006:IPR000792:IPR001789:IPR011991; KEGG: jde:Jden_1659 two component transcriptional regulator, LuxR family; PFAM: response regulator receiver; regulatory protein LuxR; SMART: regulatory protein LuxR; response regulator receiver; SPTR: D0WNC4 DNA-binding response regulator, LuxR family; PFAM: Response regulator receiver domain; Bacterial regulatory proteins, luxR family.
       0.761
Arch_1082
KEGG: bcv:Bcav_1606 hypothetical protein; SPTR: D0WNC7 Putative uncharacterized protein.
     
 0.704
Arch_1084
Methyltransferase; COGs: COG0742 N6-adenine-specific methylase; InterPro IPR004398:IPR002052:IPR016065; KEGG: kra:Krad_1371 putative methyltransferase; PFAM: Protein of unknown function methylase putative; SPTR: A7BCZ1 Putative uncharacterized protein; TIGRFAM: methyltransferase; PFAM: Conserved hypothetical protein 95; TIGRFAM: RNA methyltransferase, RsmD family.
       0.700
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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