STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pldPhospholipase D; Virulence factor affecting bacterial dissemination and survival within the host. Has magnesium-dependent catalytic activity toward sphingomyelin (SM) and acyl- and alkyl-lysophosphatidylcholine (LPC), but not toward sphingosylphosphorylcholine (SPC) and phosphatidylcholine (PC). Lysophosphatidic acid (LPA), assumed to result from LPC hydrolysis, evokes pathophysiological responses after LPA receptor internalization. Shows hemolytic activity. (318 aa)    
Predicted Functional Partners:
Arch_0413
InterPro IPR003838; KEGG: bcv:Bcav_2825 protein of unknown function DUF214; PFAM: protein of unknown function DUF214; SPTR: C5V906 ABC transporter integral membrane protein; PFAM: Predicted permease.
  
     0.692
Arch_1467
KEGG: cur:cur_1084 hypothetical protein; SPTR: B1VH03 Putative uncharacterized protein.
  
     0.571
Arch_1180
InterPro IPR009057:IPR001647:IPR012287; KEGG: cjk:jk0810 TetR family transcriptional regulator; PFAM: regulatory protein TetR; SPTR: C5VD50 Putative transcriptional regulator; PFAM: Bacterial regulatory proteins, tetR family.
  
     0.559
Arch_1098
KEGG: CaJ7_0142; hypothetical protein; SPTR: C7SZ48 Putative uncharacterized protein.
       0.526
Arch_1032
InterPro IPR009057:IPR001647:IPR012287; KEGG: mrd:Mrad2831_5885 TetR family transcriptional regulator; PFAM: regulatory protein TetR; SPTR: B1M8J9 Transcriptional regulator, TetR family; PFAM: Bacterial regulatory proteins, tetR family.
  
     0.512
Arch_1121
COGs: COG0627 esterase; InterPro IPR000801; KEGG: cgt:cgR_1064 hypothetical protein; PFAM: putative esterase; SPTR: C2KS46 Esterase; PFAM: Putative esterase.
  
     0.501
Arch_0617
LPXTG-motif cell wall anchor domain protein; InterPro IPR005519:IPR019931; KEGG: cai:Caci_5772 acid phosphatase (class B); PFAM: acid phosphatase (Class B); SPTR: B5HR56 Secreted protein; TIGRFAM: LPXTG-motif cell wall anchor domain protein; PFAM: HAD superfamily, subfamily IIIB (Acid phosphatase); TIGRFAM: LPXTG-motif cell wall anchor domain.
  
     0.488
aln
Thiol-activated cytolysin; InterPro IPR001869; KEGG: ssb:SSUBM407_0558 suilysin (hemolysin); PFAM: Thiol-activated cytolysin; SPTR: O31241 Pyolysin; PFAM: Thiol-activated cytolysin.
  
   
 0.484
Arch_1784
Transcriptional regulator, TetR family; InterPro IPR018247:IPR009057:IPR001647; KEGG: sco:SCO5906 transcriptional regulator; PFAM: regulatory protein TetR; SPTR: C0VWX7 Possible transcriptional regulator; PFAM: Bacterial regulatory proteins, tetR family.
  
     0.471
Arch_0951
Conserved hypothetical protein; COGs: COG3949 Uncharacterized membrane protein; KEGG: cdi:DIP0870 hypothetical protein; SPTR: Q8NRF4 Hypothetical membrane protein.
  
     0.453
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.