STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Arch_1112Beta-lactamase domain protein; COGs: COG1234 Metal-dependent hydrolase of the beta-lactamase superfamily III; KEGG: bcv:Bcav_2736 beta-lactamase domain protein; SPTR: D0WNI4 Metal-dependent hydrolase of the beta-lactamase superfamily III; PFAM: Metallo-beta-lactamase superfamily. (266 aa)    
Predicted Functional Partners:
Arch_1114
Domain of unknown function DUF2017; InterPro IPR018561; KEGG: bcv:Bcav_2740 hypothetical protein; PFAM: Domain of unknown function DUF2017; SPTR: D0WNI6 Putative uncharacterized protein; PFAM: Domain of unknown function (DUF2017).
 
     0.871
murI
Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.
       0.853
Arch_1115
ATP-dependent Clp protease adaptor protein ClpS; COGs: COG2127 conserved hypothetical protein; InterPro IPR014719:IPR003769; KEGG: sco:SCO2916 ATP-dependent Clp protease adaptor protein ClpS; PFAM: ATP-dependent Clp protease adaptor protein ClpS; SPTR: C4DNG9 Uncharacterized conserved protein, COG2127; PFAM: ATP-dependent Clp protease adaptor protein ClpS.
       0.845
rph
Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
  
  
 0.686
Arch_1116
Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.
     
 0.684
Arch_1109
Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
    0.551
Arch_1722
Transcriptional regulator, Crp/Fnr family; COGs: COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase; InterProIPR000595:IPR001808:IPR018490:IPR012318:IPR 014710:IPR011991; KEGG: sgr:SGR_3333 Crp/Fnr family transcriptional regulator; PFAM: cyclic nucleotide-binding; regulatory protein Crp; SMART: cyclic nucleotide-binding; regulatory protein Crp; SPTR: D0WK55 Transcriptional regulator, Crp/Fnr family; PFAM: Bacterial regulatory proteins, crp family; Cyclic nucleotide-binding domain.
 
   
 0.539
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
  
    0.538
Arch_1430
COGs: COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain); InterPro IPR001054:IPR009061; KEGG: bcv:Bcav_1154 adenylate/guanylate cyclase; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; PRIAM: Adenylate cyclase; SPTR: D0WPL7 Putative adenylate cyclase; PFAM: Adenylate and Guanylate cyclase catalytic domain.
 
   
 0.519
Arch_1111
Filamentation induced by cAMP protein Fic; COGs: COG3177 conserved hypothetical protein; InterPro IPR003812; KEGG: cgt:cgR_0191 hypothetical protein; PFAM: filamentation induced by cAMP protein Fic; SPTR: A4QAA7 Putative uncharacterized protein; PFAM: Fic/DOC family.
       0.481
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.