STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (317 aa)    
Predicted Functional Partners:
Arch_1130
Two component transcriptional regulator, winged helix family; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR011006:IPR001789:IPR000463:IPR001867; KEGG: xce:Xcel_2992 two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver; SPTR: D0YTJ0 Transcriptional regulatory protein ResD; PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal.
     
 0.784
Arch_1131
Histidine kinase; COGs: COG2205 Osmosensitive K+ channel histidine kinase; InterProIPR003594:IPR009082:IPR005467:IPR003661:IPR 004358; KEGG: xce:Xcel_2991 histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SPTR: D1BZA0 Histidine kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain.
       0.782
Arch_1133
Hypothetical protein.
       0.527
Arch_0750
COGs: COG2176 DNA polymerase III alpha subunit (gram-positive type); InterProIPR012337:IPR000305:IPR006055:IPR006054:IPR 013520; KEGG: bcv:Bcav_1900 DNA polymerase III, epsilon subunit; PFAM: Exonuclease RNase T and DNA polymerase III; Excinuclease ABC C subunit domain protein; PRIAM: DNA-directed DNA polymerase; SMART: Exonuclease; Excinuclease ABC C subunit domain protein; SPTR: D0WQL3 Putative DNA polymerase III, epsilon subunit; TIGRFAM: DNA polymerase III, epsilon subunit; PFAM: Exonuclease; GIY-YIG catalytic domain; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family.
     
 0.517
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
       0.493
Arch_1129
Major facilitator superfamily MFS_1; COGs: COG2271 Sugar phosphate permease; InterPro IPR016196:IPR005829:IPR000849:IPR011701; KEGG: ckp:ckrop_0413 glycerol-3-phosphate transporter; PFAM: major facilitator superfamily MFS_1; SPTR: C4LH87 Glycerol-3-phosphate transporter; PFAM: Major Facilitator Superfamily; TIGRFAM: glycerol-3-phosphate transporter; phosphoglycerate transporter family protein.
       0.478
menB
Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
  
   
 0.407
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.