STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Arch_1187Transcriptional regulator, MerR family; COGs: COG0789 transcriptional regulator protein; InterPro IPR009061:IPR000551:IPR015358:IPR012925; KEGG: cur:cur_0383 MerR family transcriptional regulator; PFAM: TipAS antibiotic-recognition domain protein; regulatory protein MerR; Transcription regulator MerR DNA binding; SMART: regulatory protein MerR; SPTR: B1VF04 Putative transcriptional regulator (MerR family); PFAM: MerR family regulatory protein; MerR, DNA binding; TipAS antibiotic-recognition domain. (262 aa)    
Predicted Functional Partners:
Arch_1186
KEGG: hypothetical protein; SPTR: B7GA82 Predicted protein.
       0.773
Arch_0170
Heat shock protein DnaJ domain protein; COGs: COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain; InterPro IPR001623:IPR002939:IPR008971:IPR003095; KEGG: bcv:Bcav_3707 chaperone DnaJ domain protein; PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; SMART: heat shock protein DnaJ domain protein; SPTR: D0WLG5 DnaJ protein; PFAM: DnaJ domain; DnaJ C terminal region.
  
 
 0.608
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
  
 
 0.608
sigA
RNA polymerase, sigma 70 subunit, RpoD subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
  
 
 0.527
rpoB
DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.518
Arch_1181
ABC transporter related protein; COGs: COG1132 ABC-type multidrug transport system ATPase and permease components; InterProIPR011527:IPR003439:IPR017940:IPR017871:IPR 002345:IPR003593; KEGG: ckp:ckrop_1536 putative ABC transport system; PFAM: ABC transporter related; SMART: AAA ATPase; SPTR: A7BC13 Putative uncharacterized protein; PFAM: ABC transporter transmembrane region; ABC transporter.
  
    0.516
Arch_1182
ABC transporter related protein; COGs: COG1132 ABC-type multidrug transport system ATPase and permease components; InterProIPR011527:IPR003439:IPR017940:IPR017871:IPR 003593:IPR001140; KEGG: ele:Elen_1490 ABC transporter related; PFAM: ABC transporter related; ABC transporter transmembrane region; SMART: AAA ATPase; SPTR: C0E4Q8 Putative uncharacterized protein; PFAM: ABC transporter transmembrane region; ABC transporter.
  
    0.516
Arch_1185
InterPro IPR011733; KEGG: mpa:MAP3733c hypothetical protein; PFAM: Conserved hypothetical CHP02185 integral membrane family protein; SPTR: A7BC09 Putative uncharacterized protein; TIGRFAM: conserved hypothetical protein; PFAM: Hypothetical bacterial integral membrane protein (Trep_Strep); TIGRFAM: conserved hypothetical integral membrane protein TIGR02185.
       0.510
Arch_1180
InterPro IPR009057:IPR001647:IPR012287; KEGG: cjk:jk0810 TetR family transcriptional regulator; PFAM: regulatory protein TetR; SPTR: C5VD50 Putative transcriptional regulator; PFAM: Bacterial regulatory proteins, tetR family.
     
 0.498
Arch_1183
ABC transporter related protein; COGs: COG1123 ATPase components of various ABC-type transport systems contain duplicated ATPase; InterPro IPR003439:IPR017871:IPR003593; KEGG: ckp:ckrop_1533 ABC transport system, ATP-binding protein; PFAM: ABC transporter related; SMART: AAA ATPase; SPTR: C4LKA7 ABC transport system, ATP-binding protein; PFAM: ABC transporter.
       0.497
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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