STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tatCSec-independent periplasmic protein translocase; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (245 aa)    
Predicted Functional Partners:
tatA
Sec-independent translocation protein mttA/Hcf106; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
 
 0.998
Arch_1258
InterPro IPR003998; KEGG: art:Arth_2793 hypothetical protein; SPTR: D0YUR5 Putative uncharacterized protein.
 
 
 0.925
secA
Preprotein translocase, SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
   
  
 0.822
secY
Preprotein translocase, SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
      
 0.778
ftsY
Signal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
     
 0.777
secE
Preprotein translocase, SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
  
   
 0.718
Arch_0573
Signal peptidase I; InterProIPR011056:IPR019758:IPR000223:IPR019759:IPR 015927; KEGG: bcv:Bcav_2535 signal peptidase I; PFAM: Peptidase S24/S26A/S26B, conserved region; SPTR: D0WR60 Peptidase S26A, signal peptidase I; TIGRFAM: signal peptidase I; PFAM: Peptidase S26; Peptidase S24-like; TIGRFAM: signal peptidase I, bacterial type; Belongs to the peptidase S26 family.
     
 0.621
secD
Protein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
 
   
 0.596
Arch_1245
NifC-like ABC-type porter; COGs: COG4149 ABC-type molybdate transport system permease component; InterProIPR006469:IPR011867:IPR003439:IPR000515:IPR 003593; KEGG: sgr:SGR_3501 putative ABC transporter ATPase and permease component; PFAM: ABC transporter related; binding-protein-dependent transport systems inner membrane component; SMART: AAA ATPase; SPTR: A7BBD7 Putative uncharacterized protein; TIGRFAM: NifC-like ABC-type porter; molybdate ABC transporter, inner membrane subunit; PFAM: Binding-protein-dependent transport system inner membrane component; ABC transporter; TIGRFAM: molyb [...]
 
     0.594
Arch_1244
Molybdenum ABC transporter, periplasmic molybdate-binding protein; COGs: COG0725 ABC-type molybdate transport system periplasmic component; InterPro IPR005950:IPR006059; KEGG: pac:PPA0504 putative molybdate-binding protein precursor; PFAM: extracellular solute-binding protein family 1; SPTR: Q6AAF9 Putative molybdate-binding protein; TIGRFAM: molybdenum ABC transporter, periplasmic molybdate-binding protein; PFAM: Substrate binding domain of ABC-type glycine betaine transport system; TIGRFAM: molybdenum ABC transporter, periplasmic molybdate-binding protein.
 
   
 0.576
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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