STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Arch_1278Phosphomethylpyrimidine kinase; COGs: COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; InterPro IPR013749:IPR004305:IPR016084:IPR004399; KEGG: pac:PPA0110 thiamine-phosphate pyrophosphorylase; PFAM: Phosphomethylpyrimidine kinase type-1; TENA/THI-4 domain protein; SPTR: Q6ABQ9 Putative thiamine biosynthesis protein; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase; TENA/THI-4/PQQC family; TIGRFAM: phosphomethylpyrimidine kinase. (537 aa)    
Predicted Functional Partners:
thiE
Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
 0.999
thiM
Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.
  
 0.999
Arch_1248
UBA/THIF-type NAD/FAD binding protein; COGs: COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2; InterPro IPR009036:IPR016040:IPR000594:IPR007901; KEGG: ach:Achl_2496 UBA/ThiF-type NAD/FAD binding protein; PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; SPTR: B8HBS3 UBA/THIF-type NAD/FAD binding protein; PFAM: MoeZ/MoeB domain; ThiF family.
 
  
 0.983
Arch_0394
KEGG: bcv:Bcav_2892 hypothetical protein; SPTR: D0WRX4 UBA/THIF-type NAD/FAD binding fold protein.
  
  
 0.932
Arch_1576
InterPro IPR017195; KEGG: lxx:Lxx21850 ABC-type transporter, permease protein; PFAM: ABC-type thiamin-related transport system, permease component 1, predicted; SPTR: C2BVY9 ABC superfamily ATP binding cassette transporter, permease protein; PFAM: ABC-type cobalt transport system, permease component.
  
  
 0.908
Arch_1575
ABC transporter related protein; COGs: COG1123 ATPase components of various ABC-type transport systems contain duplicated ATPase; InterPro IPR003439:IPR003339:IPR003593:IPR017871; KEGG: lxx:Lxx21860 ABC transporter, ATP-binding protein; PFAM: ABC transporter related; cobalt transport protein; SMART: AAA ATPase; SPTR: C2BVY8 ABC superfamily ATP binding cassette transporter, ABC protein; PFAM: ABC transporter; Cobalt transport protein.
  
  
 0.906
thiL
Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.
 
   
 0.847
Arch_1179
COGs: COG0516 IMP dehydrogenase/GMP reductase; InterProIPR005991:IPR018529:IPR000644:IPR013785:IPR 001093; KEGG: sco:SCO1461 inosine 5-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; CBS domain containing protein; PRIAM: IMP dehydrogenase; SMART: CBS domain containing protein; SPTR: C0W4C2 Possible IMP dehydrogenase; TIGRFAM: IMP dehydrogenase family protein; PFAM: CBS domain; IMP dehydrogenase / GMP reductase domain; TIGRFAM: inosine-5'-monophosphate dehydrogenase; IMP dehydrogenase family protein.
   
 
 0.794
Arch_1672
Permease for cytosine/purines uracil thiamine allantoin; COGs: COG1457 Purine-cytosine permease and related protein; InterPro IPR001248; KEGG: bfa:Bfae_30600 purine-cytosine permease-like transporter; PFAM: permease for cytosine/purines uracil thiamine allantoin; SPTR: C7MAT4 Purine-cytosine permease-like transporter; PFAM: Permease for cytosine/purines, uracil, thiamine, allantoin; Belongs to the purine-cytosine permease (2.A.39) family.
  
  
 0.649
Arch_1184
Cobalt transport protein; InterPro IPR003339; KEGG: car:cauri_0787 putative ABC transport system, permease protein; PFAM: cobalt transport protein; SPTR: D0YS34 Putative ABC transporter associated permease; PFAM: Cobalt transport protein.
  
  
 0.577
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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