STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
Arch_1282Two component transcriptional regulator, LuxR family; COGs: COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; InterProIPR000792:IPR001789:IPR011991:IPR011006:IPR 016032; KEGG: jde:Jden_0656 two component transcriptional regulator, LuxR family; PFAM: response regulator receiver; regulatory protein LuxR; SMART: regulatory protein LuxR; response regulator receiver; SPTR: C7R1A5 Two component transcriptional regulator, LuxR family; PFAM: Response regulator receiver domain; Bacterial regulatory proteins, luxR family. (222 aa)    
Predicted Functional Partners:
Arch_1283
COGs: COG4585 Signal transduction histidine kinase; InterPro IPR003594; KEGG: bcv:Bcav_3034 putative signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; SPTR: C0W6Q0 Signal transduction histidine kinase; PFAM: PspC domain.
 
 
 0.952
Arch_0416
COGs: COG4585 Signal transduction histidine kinase; InterPro IPR003594:IPR011712; KEGG: bcv:Bcav_2821 histidine kinase; PFAM: histidine kinase dimerisation and phosphoacceptor region; ATP-binding region ATPase domain protein; SPTR: D0WS36 Putative signal transduction histidine kinase; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
 
 
 0.875
Arch_1603
COGs: COG4585 Signal transduction histidine kinase; InterPro IPR003594:IPR011712; KEGG: kse:Ksed_01000 signal transduction histidine kinase; PFAM: histidine kinase dimerisation and phosphoacceptor region; ATP-binding region ATPase domain protein; SPTR: C2BTB8 Two component system histidine kinase; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
 
 
 0.869
Arch_0530
Histidine kinase; COGs: COG4585 Signal transduction histidine kinase; InterPro IPR011712:IPR003594; KEGG: kse:Ksed_07210 histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase dimerisation and phosphoacceptor region; SPTR: D0WNH3 Sensor histidine kinase; manually curated; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
 
 
 0.846
Arch_1281
Maltose O-acetyltransferase; COGs: COG0110 Acetyltransferase (isoleucine patch superfamily); InterPro IPR001451:IPR011004:IPR018357; KEGG: tfu:Tfu_1260 maltose O-acetyltransferase; SPTR: D0YUJ3 Maltose O-acetyltransferase; PFAM: Bacterial transferase hexapeptide (three repeats).
  
    0.775
Arch_1284
Phage shock protein C, PspC; InterPro IPR007168; KEGG: rsa:RSal33209_0977 putative stress-responsive transcriptional regulator; PFAM: PspC domain protein; SPTR: C0W6P9 Possible phage shock protein C, PspC; PFAM: PspC domain; TIGRFAM: LPXTG-motif cell wall anchor domain.
 
  
 0.691
Arch_1077
COGs: COG4585 Signal transduction histidine kinase; InterPro IPR003594:IPR003018:IPR011712; KEGG: bcv:Bcav_1613 GAF sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; GAF domain protein; histidine kinase dimerisation and phosphoacceptor region; SMART: GAF domain protein; ATP-binding region ATPase domain protein; SPTR: D0WNC3 Putative two-component sensor; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain.
 
 
 0.577
Arch_1285
Hypothetical protein; KEGG: chl:Chy400_1644 polysaccharide biosynthesis protein; SPTR: C0W6P8 Putative uncharacterized protein.
       0.534
thiE
Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
       0.511
thiM
Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.
       0.511
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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