STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Arch_1432Maf protein; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (211 aa)    
Predicted Functional Partners:
cmk
COGs: COG0283 Cytidylate kinase; InterPro IPR003136:IPR000623:IPR011994; KEGG: jde:Jden_1271 cytidylate kinase; PFAM: cytidylate kinase region; shikimate kinase; SPTR: D0WMU4 Prephenate dehydrogenase; TIGRFAM: cytidylate kinase; PFAM: Cytidylate kinase; TIGRFAM: cytidylate kinase.
 
  
  0.920
Arch_0555
COGs: COG0105 Nucleoside diphosphate kinase; InterPro IPR001564; KEGG: krh:KRH_11260 nucleoside diphosphate kinase; PFAM: nucleoside diphosphate kinase; PRIAM: Nucleoside-diphosphate kinase; SMART: nucleoside diphosphate kinase; SPTR: C0W772 Nucleoside-diphosphate kinase; PFAM: Nucleoside diphosphate kinase; Belongs to the NDK family.
  
 
  0.912
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
 
  0.907
Arch_0239
LPXTG-motif cell wall anchor domain protein; COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR004843:IPR008334:IPR019931:IPR006179; KEGG: cgt:cgR_0412 hypothetical protein; PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; SPTR: D0WQ91 5-nucleotidase; TIGRFAM: LPXTG-motif cell wall anchor domain protein; PFAM: 5'-nucleotidase, C-terminal domain; TIGRFAM: LPXTG-motif cell wall anchor domain.
  
 
  0.904
Arch_0264
ATP-binding protein; COGs: COG0572 Uridine kinase; KEGG: bcv:Bcav_3297 ATP-binding protein; SPTR: C5C1D0 ATP-binding protein.
    
  0.901
udk
COGs: COG0572 Uridine kinase; InterPro IPR006083:IPR000764:IPR017975; KEGG: cbt:CLH_0992 uridine kinase; PFAM: phosphoribulokinase/uridine kinase; SPTR: D0WPE8 Uridine kinase; TIGRFAM: uridine kinase; PFAM: Phosphoribulokinase / Uridine kinase family; TIGRFAM: uridine kinase.
    
  0.901
Arch_1707
COGs: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; InterPro IPR012833; KEGG: cdi:DIP0465 anaerobic ribonucleoside triphosphate reductase; SPTR: C0W489 Anaerobic ribonucleoside triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase.
    
  0.901
Arch_0025
5'-Nucleotidase domain protein; COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR008334:IPR006179; KEGG: mxa:MXAN_5361 putative 5'-nucleotidase; PFAM: 5'-Nucleotidase domain protein; SPTR: A8TK86 5'-Nucleotidase; PFAM: 5'-nucleotidase, C-terminal domain; Belongs to the 5'-nucleotidase family.
     
  0.900
Arch_0203
LPXTG-motif cell wall anchor domain protein; COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR004843:IPR008334:IPR019931:IPR006179; KEGG: cjk:jk1044 putative 5'-nucleotidase family protein; PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; SPTR: Q4JVE9 Putative 5'-nucleotidase family protein; TIGRFAM: LPXTG-motif cell wall anchor domain protein; PFAM: Calcineurin-like phosphoesterase; 5'-nucleotidase, C-terminal domain; TIGRFAM: LPXTG-motif cell wall anchor domain; Belongs to the 5'-nucleotidase family.
     
  0.900
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
     
  0.900
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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