STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (342 aa)    
Predicted Functional Partners:
Arch_0346
COGs: COG0567 2-oxoglutarate dehydrogenase complex dehydrogenase (E1); InterPro IPR001078:IPR001017:IPR005475:IPR011603; KEGG: bcv:Bcav_1274 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: Transketolase central region; dehydrogenase E1 component; catalytic domain of components of various dehydrogenase complexes; SPTR: D0WRR3 Oxoglutarate dehydrogenase (Succinyl-transferring), E1 component; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Dehydrogenase E1 component; Transketolase, pyrimidine binding domain; TIGRFAM: 2- [...]
   
 0.980
Arch_1521
COGs: COG1207 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains); InterPro IPR001228:IPR011004; KEGG: jde:Jden_1943 UDP-N-acetylglucosamine pyrophosphorylase; PFAM: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; PRIAM: Glucosamine-1-phosphate N-acetyltransferase; SPTR: D0WQ25 UDP-N-acetylglucosamine diphosphorylase; PFAM: Nucleotidyl transferase; TIGRFAM: UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase.
 
  
 0.969
Arch_0880
Transketolase; COGs: COG0021 Transketolase; InterProIPR009014:IPR005474:IPR015941:IPR005478:IPR 005475:IPR005476; KEGG: jde:Jden_1264 transketolase; PFAM: Transketolase domain protein; Transketolase central region; SPTR: D0WMT7 Transketolase; TIGRFAM: transketolase; PFAM: Transketolase, thiamine diphosphate binding domain; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain; TIGRFAM: transketolase, bacterial and yeast; Belongs to the transketolase family.
   
 
 0.950
Arch_0475
COGs: COG0698 Ribose 5-phosphate isomerase RpiB; InterPro IPR003500:IPR011860; KEGG: bcv:Bcav_2620 ribose 5-phosphate isomerase; PFAM: Ribose/galactose isomerase; SPTR: D1BJV4 Ribose 5-phosphate isomerase; TIGRFAM: ribose 5-phosphate isomerase; sugar-phosphate isomerase, RpiB/LacA/LacB family; manually curated; PFAM: Ribose/Galactose Isomerase; TIGRFAM: ribose 5-phosphate isomerase; sugar-phosphate isomerases, RpiB/LacA/LacB family.
  
 
 0.919
Arch_1476
COGs: COG0698 Ribose 5-phosphate isomerase RpiB; InterPro IPR003500:IPR011860; KEGG: pac:PPA2324 ribose 5-phosphate isomerase; PFAM: Ribose/galactose isomerase; SPTR: Q3LFG7 Ribose-5-phosphate isomerase 2; TIGRFAM: ribose 5-phosphate isomerase; sugar-phosphate isomerase, RpiB/LacA/LacB family; PFAM: Ribose/Galactose Isomerase; TIGRFAM: ribose 5-phosphate isomerase; sugar-phosphate isomerases, RpiB/LacA/LacB family.
  
 
 0.919
rbsK
Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
  
 0.919
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
 
  
 0.903
Arch_0131
Phosphoglucomutase, alpha-D-glucose phosphate-specific; COGs: COG0033 Phosphoglucomutase; InterProIPR005844:IPR005845:IPR005846:IPR005843:IPR 016055:IPR005852:IPR016066; KEGG: xce:Xcel_0168 phosphoglucomutase, alpha-D-glucose phosphate-specific; PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase; SPTR: D0WKG6 Phosphoglucomutase, alpha-D-glucose phosphate-specific; TIGRFAM: phosphoglucomutase, alpha [...]
   
 
 0.901
Arch_0736
COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterProIPR013027:IPR000815:IPR016156:IPR012999:IPR 004099:IPR006258; KEGG: jde:Jden_1475 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; SPTR: D0WQM8 Dihydrolipoyl dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase.
   
 0.893
rplY
Ribosomal 5S rRNA E-loop binding protein Ctc/L25/TL5; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
  
  
 0.885
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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