STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mscLLarge conductance mechanosensitive channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. (124 aa)    
Predicted Functional Partners:
Arch_0517
COGs: COG0192 S-adenosylmethionine synthetase; InterPro IPR001412:IPR002133; KEGG: pac:PPA1587 S-adenosylmethionine synthetase; PFAM: S-adenosylmethionine synthetase; PRIAM: Methionine adenosyltransferase; SPTR: C2KNY0 S-adenosylmethionine synthetase; PFAM: S-adenosylmethionine synthetase, C-terminal domain; S-adenosylmethionine synthetase, central domain; S-adenosylmethionine synthetase, N-terminal domain; TIGRFAM: S-adenosylmethionine synthetase.
   
    0.712
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
   
    0.712
Arch_0493
COGs: COG0521 Molybdopterin biosynthesis protein; InterPro IPR001453:IPR008284; KEGG: tfu:Tfu_0376 molybdopterin adenylyltransferase; PFAM: molybdopterin binding domain; SPTR: Q47T03 Molybdopterin adenylyltransferase; PFAM: Probable molybdopterin binding domain.
     
 0.690
Arch_1611
SAF domain protein; InterPro IPR013974; KEGG: bcv:Bcav_0901 SAF domain protein; PFAM: SAF domain protein; SPTR: D0WJR4 Flp pilus assembly protein CpaB family protein; PFAM: SAF domain; TIGRFAM: Flp pilus assembly protein CpaB.
       0.671
nhaA
Na+/H+ antiporter NhaA; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
     
 0.572
Arch_1610
COGs: COG0212 5-formyltetrahydrofolate cyclo-ligase; InterPro IPR002698; KEGG: jde:Jden_1969 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; SPTR: D0WJR1 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase family; TIGRFAM: 5,10-methenyltetrahydrofolate synthetase.
     
 0.537
nuoA
NADH-ubiquinone/plastoquinone oxidoreductase chain 3; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 3 family.
     
 0.535
rpmB
COGs: COG0227 Ribosomal protein L28; InterPro IPR001383; KEGG: kra:Krad_0287 ribosomal protein L28; PFAM: ribosomal protein L28; SPTR: C2AMB1 LSU ribosomal protein L28P; TIGRFAM: ribosomal protein L28; PFAM: Ribosomal L28 family; TIGRFAM: ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family.
     
 0.510
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
       0.493
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
     
 0.459
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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