STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-expression
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[Homology]
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Arch_1618Iron (metal) dependent repressor, DtxR family; COGs: COG1321 Mn-dependent transcriptional regulator protein; InterPro IPR001367:IPR008988:IPR007167:IPR011991; KEGG: jde:Jden_1989 iron (metal) dependent repressor, DtxR family; PFAM: iron dependent repressor; FeoA family protein; SMART: iron dependent repressor; SPTR: C7R0G3 Iron (Metal) dependent repressor, DtxR family; PFAM: FeoA domain; Iron dependent repressor, metal binding and dimerisation domain; Iron dependent repressor, N-terminal DNA binding domain. (225 aa)    
Predicted Functional Partners:
Arch_0688
Ferric uptake regulator, Fur family; COGs: COG0735 Fe2+/Zn2+ uptake regulation protein; InterPro IPR002481; KEGG: bcv:Bcav_1772 ferric uptake regulator, Fur family; PFAM: ferric-uptake regulator; SPTR: C5C4Q0 Ferric uptake regulator, Fur family; PFAM: Ferric uptake regulator family; Belongs to the Fur family.
  
  
 0.525
Arch_1006
ABC transporter related protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
   
   0.519
sigA
RNA polymerase, sigma 70 subunit, RpoD subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
  
  
 0.495
Arch_1617
NLP/P60 protein; COGs: COG0791 Cell wall-associated hydrolase (invasion-associated protein); InterPro IPR006162:IPR000064; KEGG: bcv:Bcav_0883 NLP/P60 protein; PFAM: NLP/P60 protein; SPTR: C0W426 NLP/P60 family protein; PFAM: NlpC/P60 family.
       0.483
Arch_1117
Type III restriction protein res subunit; COGs: COG1061 DNA or RNA helicase of superfamily II; InterPro IPR014021:IPR014001:IPR006935; KEGG: art:Arth_2588 type III restriction enzyme, res subunit; PFAM: type III restriction protein res subunit; SMART: DEAD-like helicase; SPTR: D0WNJ0 Putative DNA or RNA helicase of superfamily II; PFAM: Type III restriction enzyme, res subunit.
 
     0.456
Arch_1619
COGs: COG2252 Permease; InterPro IPR006043; KEGG: kra:Krad_1382 xanthine/uracil/vitamin C permease; PFAM: Xanthine/uracil/vitamin C permease; SPTR: D0WJT1 Xanthine/uracil permease family protein; PFAM: Permease family.
       0.446
rpoB
DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.416
Arch_0710
NAD-dependent epimerase/dehydratase; COGs: COG1090 nucleoside-diphosphate sugar epimerase; InterPro IPR016040:IPR010099:IPR001509:IPR013549; KEGG: sma:SAV_6013 NAD-dependent epimerase/dehydratase family protein; PFAM: NAD-dependent epimerase/dehydratase; domain of unknown function DUF1731; SPTR: Q82AP3 Putative NAD dependent epimerase/dehydratase family; PFAM: NAD dependent epimerase/dehydratase family; Domain of unknown function (DUF1731); TIGRFAM: conserved hypothetical protein TIGR01777.
   
    0.411
Arch_1167
COGs: COG1087 UDP-glucose 4-epimerase; InterPro IPR016040:IPR005886:IPR001509:IPR008089; KEGG: blj:BLD_1768 UDP-glucose 4-epimerase; PFAM: NAD-dependent epimerase/dehydratase; SPTR: B9TTH2 GalE1; TIGRFAM: UDP-glucose 4-epimerase; PFAM: NAD dependent epimerase/dehydratase family; TIGRFAM: UDP-glucose-4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family.
     
 0.408
Arch_1620
Mannose-6-phosphate isomerase, class I; COGs: COG1482 Phosphomannose isomerase; InterProIPR018050:IPR011051:IPR016305:IPR001250:IPR 014710; KEGG: bcv:Bcav_0860 mannose-6-phosphate isomerase, class I; PFAM: mannose-6-phosphate isomerase type I; PRIAM: Mannose-6-phosphate isomerase; SPTR: D0WJT2 Mannose-6-phosphate isomerase, class I; TIGRFAM: mannose-6-phosphate isomerase, class I; PFAM: Phosphomannose isomerase type I; TIGRFAM: mannose-6-phosphate isomerase, class I.
       0.403
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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