STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
kbl2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (396 aa)    
Predicted Functional Partners:
Arch_1637
Alcohol dehydrogenase GroES domain protein; COGs: COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenase; InterProIPR002328:IPR011032:IPR016040:IPR013154:IPR 013149; KEGG: kse:Ksed_10170 L-threonine 3-dehydrogenase; PFAM: Alcohol dehydrogenase GroES domain protein; Alcohol dehydrogenase zinc-binding domain protein; SPTR: C0W4J4 L-threonine 3-dehydrogenase; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase; TIGRFAM: L-threonine 3-dehydrogenase.
 
 
 0.997
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.935
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
  
  
 0.682
Arch_0254
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
     
 0.662
dxs
Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.
   
  
 0.634
clpX
ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
   
 0.560
Arch_1638
H(+)-transporting two-sector ATPase; COGs: COG0168 Trk-type K+ transport systems membrane components; InterPro IPR003445; KEGG: krh:KRH_15110 putative cation transporter; PFAM: cation transporter; PRIAM: H(+)-transporting two-sector ATPase; SPTR: C2BVK7 Possible H(+)-transporting two-sector ATPase; PFAM: Cation transport protein; TIGRFAM: potassium uptake protein, TrkH family.
       0.538
Arch_1635
Hypothetical protein; KEGG: jde:Jden_1612 LPXTG-motif cell wall anchor domain protein; SPTR: C7R5I7 LPXTG-motif cell wall anchor domain protein; TIGRFAM: LPXTG-motif cell wall anchor domain.
       0.519
Arch_1639
TrkA-N domain protein; COGs: COG0569 K+ transport systems NAD-binding component; InterPro IPR016040:IPR003148:IPR006037; KEGG: sro:Sros_6144 TrkA-N; PFAM: TrkA-N domain protein; TrkA-C domain protein; SPTR: D0YQI4 TrkA-N; PFAM: TrkA-N domain; TrkA-C domain.
       0.510
Arch_0346
COGs: COG0567 2-oxoglutarate dehydrogenase complex dehydrogenase (E1); InterPro IPR001078:IPR001017:IPR005475:IPR011603; KEGG: bcv:Bcav_1274 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: Transketolase central region; dehydrogenase E1 component; catalytic domain of components of various dehydrogenase complexes; SPTR: D0WRR3 Oxoglutarate dehydrogenase (Succinyl-transferring), E1 component; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Dehydrogenase E1 component; Transketolase, pyrimidine binding domain; TIGRFAM: 2- [...]
     
 0.488
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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