STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Arch_1637Alcohol dehydrogenase GroES domain protein; COGs: COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenase; InterProIPR002328:IPR011032:IPR016040:IPR013154:IPR 013149; KEGG: kse:Ksed_10170 L-threonine 3-dehydrogenase; PFAM: Alcohol dehydrogenase GroES domain protein; Alcohol dehydrogenase zinc-binding domain protein; SPTR: C0W4J4 L-threonine 3-dehydrogenase; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase; TIGRFAM: L-threonine 3-dehydrogenase. (352 aa)    
Predicted Functional Partners:
kbl
2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
 
 
 0.997
Arch_0083
Transcriptional regulator, MarR family; COGs: COG4750 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes; InterPro IPR000835:IPR002573:IPR011009; KEGG: apv:Apar_1003 transcriptional regulator, MarR family; PFAM: Choline/ethanolamine kinase; regulatory protein MarR; SPTR: A7BEG2 Putative uncharacterized protein; PFAM: Choline/ethanolamine kinase; Nucleotidyl transferase.
  
  
 0.687
Arch_1638
H(+)-transporting two-sector ATPase; COGs: COG0168 Trk-type K+ transport systems membrane components; InterPro IPR003445; KEGG: krh:KRH_15110 putative cation transporter; PFAM: cation transporter; PRIAM: H(+)-transporting two-sector ATPase; SPTR: C2BVK7 Possible H(+)-transporting two-sector ATPase; PFAM: Cation transport protein; TIGRFAM: potassium uptake protein, TrkH family.
       0.537
Arch_1635
Hypothetical protein; KEGG: jde:Jden_1612 LPXTG-motif cell wall anchor domain protein; SPTR: C7R5I7 LPXTG-motif cell wall anchor domain protein; TIGRFAM: LPXTG-motif cell wall anchor domain.
       0.524
Arch_1639
TrkA-N domain protein; COGs: COG0569 K+ transport systems NAD-binding component; InterPro IPR016040:IPR003148:IPR006037; KEGG: sro:Sros_6144 TrkA-N; PFAM: TrkA-N domain protein; TrkA-C domain protein; SPTR: D0YQI4 TrkA-N; PFAM: TrkA-N domain; TrkA-C domain.
       0.510
Arch_0049
COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590:IPR016162:IPR010061:IPR016161; KEGG: pac:PPA0461 methylmalonic acid semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: C0W6L2 Methylmalonate-semialdehyde dehydrogenase (Acylating); TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde dehydrogenase family; TIGRFAM: methylmalonic acid semialdehyde dehydrogenase.
  
 
 0.496
Arch_1458
PTS system, glucose subfamily, IIA subunit; COGs: COG1263 Phosphotransferase system IIC components glucose/maltose/N-acetylglucosamine-specific; InterProIPR001127:IPR001996:IPR013013:IPR018113:IPR 003352:IPR011055; KEGG: cdi:DIP1151 PTS system, glucose-specific IIABC component; PFAM: sugar-specific permease EIIA 1 domain; phosphotransferase system EIIC; Phosphotransferase system EIIB/cysteine, phosphorylation site; PRIAM: Protein-N(pi)-phosphohistidine--sugar phosphotransferase; SPTR: C2CRZ1 Protein-N(Pi)-phosphohistidine--sugar phosphotransferase; TIGRFAM: PTS system, glucose subfamil [...]
  
  
 0.443
ispD
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
  
  
 0.430
Arch_1670
FAD-dependent pyridine nucleotide-disulfide oxidoreductase; COGs: COG0446 NAD(FAD)-dependent dehydrogenase; InterPro IPR001763:IPR016156:IPR013027:IPR004099; KEGG: cdi:DIP1748 putative oxidase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; Rhodanese domain protein; SMART: Rhodanese domain protein; SPTR: C2CQM4 CoA-disulfide reductase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Rhodanese-like domain.
  
  
 0.407
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
Server load: very high (100%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.