STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Arch_1658RNA methyltransferase, TrmH family, group 3; COGs: COG0566 rRNA methylase; InterPro IPR013123:IPR001537:IPR004441; KEGG: xce:Xcel_2952 RNA methyltransferase, TrmH family, group 3; PFAM: tRNA/rRNA methyltransferase (SpoU); RNA 2-O ribose methyltransferase substrate binding; SPTR: D0WJY2 RNA methyltransferase, TrmH family, group 3; TIGRFAM: RNA methyltransferase, TrmH family, group 3; PFAM: SpoU rRNA Methylase family; RNA 2'-O ribose methyltransferase substrate binding; TIGRFAM: rRNA methylase, putative, group 3; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA [...] (327 aa)    
Predicted Functional Partners:
cysS
COGs: COG0215 Cysteinyl-tRNA synthetase; InterProIPR009080:IPR015803:IPR015273:IPR002308:IPR 014729; KEGG: bcv:Bcav_0780 cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase class Ia; Cysteinyl-tRNA synthetase class Ia DALR; PRIAM: Cysteine--tRNA ligase; SPTR: D0WJY3 Cysteine--tRNA ligase; TIGRFAM: cysteinyl-tRNA synthetase; PFAM: tRNA synthetases class I (C) catalytic domain; DALR domain; TIGRFAM: cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 
 0.903
Arch_1657
Hypothetical protein; KEGG: rsa:RSal33209_2038 putative proteasome component; SPTR: D0WJY1 50S ribosomal protein L12P.
       0.801
rplK
Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
 
   0.789
Arch_1656
Protein of unknown function DUF437; COGs: COG4405 conserved hypothetical protein; InterPro IPR015947:IPR007374; KEGG: lmc:Lm4b_02824 hypothetical protein; PFAM: protein of unknown function DUF437; SPTR: D0WJY0 Putative uncharacterized protein; PFAM: ASCH domain.
       0.782
pheT
COGs: COG0072 Phenylalanyl-tRNA synthetase beta subunit; InterProIPR020825:IPR005121:IPR016027:IPR009061:IPR 004532:IPR002547:IPR012340:IPR005147:IPR005146; KEGG: jde:Jden_1109 phenylalanyl-tRNA synthetase, beta subunit; PFAM: B3/4 domain protein; t-RNA-binding domain protein; tRNA synthetase B5; ferredoxin-fold anticodon-binding; SPTR: D0WN31 Phenylalanyl-tRNA synthetase, beta subunit; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; PFAM: tRNA synthetase B5 domain; B3/4 domain; Ferredoxin-fold anticodon binding domain; Putative tRNA binding domain; TIGRFAM: phenylalanyl-tRNA synt [...]
 
  
 0.625
rplC
50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.
 
 
 
 0.618
Arch_0964
tRNA/rRNA methyltransferase (SpoU); COGs: COG0566 rRNA methylase; InterPro IPR013123:IPR001537; KEGG: xce:Xcel_1319 tRNA/rRNA methyltransferase (SpoU); PFAM: tRNA/rRNA methyltransferase (SpoU); RNA 2-O ribose methyltransferase substrate binding; SPTR: D0WN38 Putative 23S rRNA methyltransferase; PFAM: SpoU rRNA Methylase family; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
  
     0.578
Arch_0683
Pseudouridine synthase, RluA family; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family.
 
 
 0.551
Arch_1655
COGs: COG2233 Xanthine/uracil permease; InterPro IPR006043:IPR006042; KEGG: bcv:Bcav_0274 uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; SPTR: C2BTD4 NCS2 family nucleobase:cation symporter-2; TIGRFAM: uracil-xanthine permease; PFAM: Permease family; TIGRFAM: uracil-xanthine permease.
  
    0.532
rplT
Ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.
 
   0.527
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.