STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Gene Fusion
Cooccurrence
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[Homology]
Score
Arch_1705Methyltransferase small; COGs: COG2890 Methylase of polypeptide chain release factors; InterPro IPR002052:IPR007848; KEGG: kse:Ksed_25140 methyltransferase family protein; PFAM: methyltransferase small; SPTR: C7NG68 Methyltransferase family protein; PFAM: Methyltransferase small domain; Belongs to the methyltransferase superfamily. (496 aa)    
Predicted Functional Partners:
prfA
Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
  
 
 0.882
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
       0.730
Arch_1702
COGs: COG2812 DNA polymerase III gamma/tau subunits; KEGG: xce:Xcel_0355 DNA polymerase III, delta prime subunit; SPTR: D1BVC3 DNA polymerase III, delta prime subunit; PFAM: ATPase family associated with various cellular activities (AAA); TIGRFAM: DNA polymerase III, delta' subunit.
 
    0.704
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
   0.680
Arch_1117
Type III restriction protein res subunit; COGs: COG1061 DNA or RNA helicase of superfamily II; InterPro IPR014021:IPR014001:IPR006935; KEGG: art:Arth_2588 type III restriction enzyme, res subunit; PFAM: type III restriction protein res subunit; SMART: DEAD-like helicase; SPTR: D0WNJ0 Putative DNA or RNA helicase of superfamily II; PFAM: Type III restriction enzyme, res subunit.
 
 
   0.621
Arch_1701
TAP domain protein; InterPro IPR000073:IPR013595; KEGG: xce:Xcel_0356 TAP domain protein; PFAM: TAP domain protein; alpha/beta hydrolase fold; SPTR: D0WK12 Putative uncharacterized protein; PFAM: TAP-like protein.
  
    0.557
Arch_0762
KEGG: jde:Jden_1426 hypothetical protein; SPTR: C7R4M1 Putative uncharacterized protein.
  
     0.483
Arch_0687
COGs: COG0586 membrane-associated protein; KEGG: nml:Namu_0645 SNARE associated Golgi protein; SPTR: C0W0A7 Putative uncharacterized protein; PFAM: SNARE associated Golgi protein.
  
     0.476
atpE
ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
  
   0.471
Arch_1118
KEGG: bcv:Bcav_2744 hypothetical protein; SPTR: D0WNJ1 Putative uncharacterized protein; PFAM: Protein of unknown function (DUF3039).
 
     0.458
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.