Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
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rtcARNA 3'-phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. (334 aa)    
Predicted Functional Partners:
rps4
Ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
   
 0.959
rps6e
PFAM: Ribosomal protein S6e; KEGG: mbu:Mbur_0224 30S ribosomal protein S6e; Belongs to the eukaryotic ribosomal protein eS6 family.
   
  0.947
rps11
Ribosomal protein S11P; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family.
   
  0.943
ADI72962.1
PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: mbu:Mbur_1767 FAD-dependent pyridine nucleotide-disulphide oxidoreductase.
     
 0.936
ADI74574.1
TIGRFAM: KH domain protein; PFAM: K Homology, type 1, subgroup; KEGG: mbu:Mbur_0948 putative RNA-processing protein; SMART: KH domain protein.
  
 
 0.918
ADI75031.1
PFAM: Pre-mRNA processing ribonucleoprotein, binding domain protein; NOSIC domain protein; KEGG: mbu:Mbur_1562 rRNA biogenesis protein Nop56/Nop58.
 
 
 0.915
csl4
RNA binding protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.
  
  0.908
rrp42
3' exoribonuclease; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.
  
 0.903
rtcB
PFAM: protein of unknown function UPF0027; KEGG: mma:MM_1538 replication factor C subunit; Belongs to the RtcB family.
 
  
 0.889
rps3ae
PFAM: ribosomal protein S3Ae; KEGG: mbu:Mbur_2336 30S ribosomal protein S3Ae; Belongs to the eukaryotic ribosomal protein eS1 family.
  
  0.865
Your Current Organism:
Methanohalobium evestigatum
NCBI taxonomy Id: 644295
Other names: M. evestigatum Z-7303, Methanohalobium evestigatum Z-7303, Methanohalobium evestigatum str. Z-7303, Methanohalobium evestigatum strain Z-7303
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