Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ADI73003.1PFAM: thiamine biosynthesis protein ThiC; KEGG: mac:MA0261 thiamine biosynthesis protein ThiC. (419 aa)    
Predicted Functional Partners:
ADI73113.1
KEGG: mbu:Mbur_2182 phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; Phosphomethylpyrimidine kinase.
 
 
 0.995
ADI73004.1
F420-dependent oxidoreductase; KEGG: mac:MA3512 hypothetical protein; TIGRFAM: F420-dependent oxidoreductase; PFAM: protein of unknown function DUF129.
       0.936
ADI73002.1
PFAM: methylenetetrahydrofolate reductase; KEGG: mbu:Mbur_1847 methylenetetrahydrofolate reductase.
     
 0.913
thiC
Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 
0.906
purM
Phosphoribosylformylglycinamidine cyclo-ligase; KEGG: mbu:Mbur_1979 phosphoribosylaminoimidazole synthetase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein.
    
 0.823
ADI73001.1
KEGG: mac:MA3515 hypothetical protein.
       0.801
ADI73000.1
TIGRFAM: dihydropteroate synthase; KEGG: mbu:Mbur_1815 dihydropteroate synthase; PFAM: dihydropteroate synthase DHPS.
     
 0.713
ADI73941.1
KEGG: mbu:Mbur_0377 hypothetical protein.
  
  
 0.676
thi4
Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
  
  
 0.648
ADI73005.1
PFAM: Thioredoxin domain; KEGG: mma:MM_0436 thioredoxin.
  
  
 0.578
Your Current Organism:
Methanohalobium evestigatum
NCBI taxonomy Id: 644295
Other names: M. evestigatum Z-7303, Methanohalobium evestigatum Z-7303, Methanohalobium evestigatum str. Z-7303, Methanohalobium evestigatum strain Z-7303
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.