STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADI73078.1AAA ATPase central domain protein; KEGG: mvu:Metvu_1206 AAA family ATPase, CDC48 subfamily; PFAM: AAA ATPase central domain protein; SMART: AAA ATPase. (260 aa)    
Predicted Functional Partners:
ADI73077.1
KEGG: pfh:PFHG_05169 hypothetical protein.
       0.777
ADI73079.1
KEGG: pyo:PY00055 hypothetical protein.
       0.773
pan
26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...]
 
 0.717
ADI73323.1
SMART: AAA ATPase; TIGRFAM: 26S proteasome subunit P45 family; KEGG: mbu:Mbur_2301 proteasome-activating nucleotidase; PFAM: AAA ATPase central domain protein; Belongs to the AAA ATPase family.
 
 0.716
ADI73080.1
PFAM: SMC domain protein; KEGG: sto:ST2117 hypothetical protein.
 
 
 0.669
ADI73119.1
KEGG: mbu:Mbur_2106 AAA ATPase; PFAM: AAA ATPase central domain protein; SMART: AAA ATPase; Belongs to the AAA ATPase family.
  
 
 0.557
psmA
Proteasome endopeptidase complex, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
  
 0.545
psmB
Proteasome endopeptidase complex, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
  
 0.527
dnaK
Chaperone protein DnaK; Acts as a chaperone.
 
 0.514
rpl40e
KEGG: mac:MA3970 50S ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family.
  
 0.508
Your Current Organism:
Methanohalobium evestigatum
NCBI taxonomy Id: 644295
Other names: M. evestigatum Z-7303, Methanohalobium evestigatum Z-7303, Methanohalobium evestigatum str. Z-7303, Methanohalobium evestigatum strain Z-7303
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.