Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
ADI73609.1PFAM: Protein of unknown function DUF460; KEGG: mac:MA2517 hypothetical protein. (665 aa)    
Predicted Functional Partners:
ADI73610.1
PFAM: RIO-like kinase; RIO2 kinase, winged helix domain protein; KEGG: mac:MA2518 hypothetical protein; SMART: protein of unknown function RIO1.
 
     0.907
ADI74731.1
KEGG: mba:Mbar_A3598 hypothetical protein.
 
     0.647
ADI74609.1
PFAM: conserved hypothetical protein; KEGG: mbu:Mbur_1891 hypothetical protein.
  
     0.641
ADI75004.1
PFAM: PRC-barrel domain protein; KEGG: mbu:Mbur_2035 PRC-barrel protein.
  
     0.632
tfe
Transcription factor TFIIE, alpha subunit; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongatio [...]
  
   
 0.630
ADI73362.1
PFAM: Protein of unknown function DUF1628; KEGG: mbu:Mbur_1027 hypothetical protein.
  
     0.612
ADI73471.1
PFAM: conserved hypothetical protein; KEGG: mac:MA3684 hypothetical protein.
  
     0.612
ADI74003.1
PFAM: Exosortase EpsH-related; KEGG: mbu:Mbur_2196 hypothetical protein.
 
     0.605
ADI74124.1
PFAM: Oligosaccharyl transferase STT3 subunit; KEGG: mbu:Mbur_1579 transmembrane oligosaccharyl transferase.
  
     0.604
ADI74526.1
PFAM: Protein of unknown function DUF2072, Zinc-ribbon; KEGG: mbu:Mbur_0142 hypothetical protein.
  
     0.595
Your Current Organism:
Methanohalobium evestigatum
NCBI taxonomy Id: 644295
Other names: M. evestigatum Z-7303, Methanohalobium evestigatum Z-7303, Methanohalobium evestigatum str. Z-7303, Methanohalobium evestigatum strain Z-7303
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