Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADI73648.1PFAM: nitroreductase; KEGG: mbu:Mbur_0707 nitroreductase. (180 aa)    
Predicted Functional Partners:
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
       0.801
ADI73645.1
KEGG: mba:Mbar_A0218 acetolactate synthase 3 catalytic subunit; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding.
  
  
 0.743
ADI73646.1
TIGRFAM: acetolactate synthase, small subunit; KEGG: mac:MA3791 acetolactate synthase 3 regulatory subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein.
       0.732
ADI74907.1
Methanogenesis marker protein 1; KEGG: mbu:Mbur_2069 hypothetical protein; TIGRFAM: methanogenesis marker protein 1; PFAM: protein of unknown function DUF181.
  
  
 0.624
ADI73272.1
PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: gme:Gmet_2649 glyoxalase/bleomycin resistance protein/dioxygenase.
  
  
 0.505
ADI74091.1
PFAM: Abortive infection protein; KEGG: xce:Xcel_2718 abortive infection protein.
  
  
 0.485
ADI74062.1
PFAM: ABC-2 type transporter; KEGG: nth:Nther_0906 ABC-2 type transporter.
  
  
 0.476
ADI74143.1
PFAM: ABC-2 type transporter; KEGG: mpl:Mpal_2468 ABC-2 type transporter.
  
  
 0.476
ADI74517.1
PFAM: ABC-2 type transporter; KEGG: nth:Nther_0906 ABC-2 type transporter.
  
  
 0.476
ADI75022.1
PFAM: ABC-2 type transporter; KEGG: mbu:Mbur_1716 ABC transporter, inner membrane subunit.
  
  
 0.476
Your Current Organism:
Methanohalobium evestigatum
NCBI taxonomy Id: 644295
Other names: M. evestigatum Z-7303, Methanohalobium evestigatum Z-7303, Methanohalobium evestigatum str. Z-7303, Methanohalobium evestigatum strain Z-7303
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