STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADI73689.1TIGRFAM: DNA ligase D, 3'-phosphoesterase domain protein; KEGG: mma:MM_0209 hypothetical protein. (152 aa)    
Predicted Functional Partners:
pcn
Proliferating cell nuclear antigen PcnA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
  
 0.918
lig
DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
   
 0.911
ADI73921.1
PHP domain protein; KEGG: mtp:Mthe_1315 phosphotransferase domain-containing protein; PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; DNA polymerase X; Helix-hairpin-helix DNA-binding class 1.
  
 0.809
fen
Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...]
  
 0.793
ADI73370.1
Deoxyribonuclease I; PFAM: Endonuclease/exonuclease/phosphatase; KEGG: mba:Mbar_A2969 hypothetical protein; SMART: deoxyribonuclease I.
  
 
 0.748
ADI74580.1
TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; KEGG: mbu:Mbur_1688 replicative DNA polymerase I; SMART: DNA-directed DNA polymerase B.
  
 0.703
ADI73649.1
PFAM: DNA topoisomerase type IA central domain protein; TOPRIM domain protein; DNA topoisomerase type IA zn finger domain protein; KEGG: mbu:Mbur_0705 DNA topoisomerase; SMART: DNA topoisomerase I DNA-binding; DNA topoisomerase I ATP-binding; Toprim sub domain protein.
  
 0.694
ADI73006.1
KEGG: mma:MM_0428 hypothetical protein.
 
 0.585
polB
DNA-directed DNA polymerase; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family.
   
 
 0.551
ADI72936.1
KEGG: mbu:Mbur_1734 peptidase S26B, signal peptidase; TIGRFAM: peptidase S26B, signal peptidase; PFAM: Peptidase S24/S26A/S26B, conserved region.
    
 0.518
Your Current Organism:
Methanohalobium evestigatum
NCBI taxonomy Id: 644295
Other names: M. evestigatum Z-7303, Methanohalobium evestigatum Z-7303, Methanohalobium evestigatum str. Z-7303, Methanohalobium evestigatum strain Z-7303
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.