| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADI73780.1 | ADI73781.1 | Metev_0882 | Metev_0883 | KEGG: mac:MA3299 hypothetical protein; TIGRFAM: methanogenesis marker 16 metalloprotein; PFAM: protein of unknown function DUF39. | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: mma:MM_0134 sulfopyruvate decarboxylase alpha chain. | 0.769 |
| ADI73781.1 | ADI73780.1 | Metev_0883 | Metev_0882 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: mma:MM_0134 sulfopyruvate decarboxylase alpha chain. | KEGG: mac:MA3299 hypothetical protein; TIGRFAM: methanogenesis marker 16 metalloprotein; PFAM: protein of unknown function DUF39. | 0.769 |
| ADI73781.1 | ADI73800.1 | Metev_0883 | Metev_0904 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: mma:MM_0134 sulfopyruvate decarboxylase alpha chain. | KEGG: mbu:Mbur_2419 methyl-coenzyme M reductase operon protein C; TIGRFAM: methyl-coenzyme M reductase I operon protein C; PFAM: Methyl-coenzyme M reductase protein C. | 0.831 |
| ADI73781.1 | cofC | Metev_0883 | Metev_0264 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: mma:MM_0134 sulfopyruvate decarboxylase alpha chain. | 2-phospho-L-lactate guanylyltransferase CofC; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. | 0.853 |
| ADI73781.1 | cofD | Metev_0883 | Metev_0504 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: mma:MM_0134 sulfopyruvate decarboxylase alpha chain. | LPPG domain protein containing protein; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | 0.825 |
| ADI73781.1 | cofG | Metev_0883 | Metev_0266 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: mma:MM_0134 sulfopyruvate decarboxylase alpha chain. | 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofG subunit; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. | 0.814 |
| ADI73781.1 | glyA | Metev_0883 | Metev_0066 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: mma:MM_0134 sulfopyruvate decarboxylase alpha chain. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.768 |
| ADI73781.1 | mtd | Metev_0883 | Metev_1727 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: mma:MM_0134 sulfopyruvate decarboxylase alpha chain. | Methylenetetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. | 0.807 |
| ADI73781.1 | mtrA | Metev_0883 | Metev_2020 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: mma:MM_0134 sulfopyruvate decarboxylase alpha chain. | Tetrahydromethanopterin S-methyltransferase, subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. | 0.867 |
| ADI73781.1 | mtrB | Metev_0883 | Metev_2019 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: mma:MM_0134 sulfopyruvate decarboxylase alpha chain. | Tetrahydromethanopterin S-methyltransferase subunit B; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. | 0.851 |
| ADI73781.1 | mtrD | Metev_0883 | Metev_2017 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: mma:MM_0134 sulfopyruvate decarboxylase alpha chain. | Tetrahydromethanopterin S-methyltransferase, subunit D; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. | 0.855 |
| ADI73800.1 | ADI73781.1 | Metev_0904 | Metev_0883 | KEGG: mbu:Mbur_2419 methyl-coenzyme M reductase operon protein C; TIGRFAM: methyl-coenzyme M reductase I operon protein C; PFAM: Methyl-coenzyme M reductase protein C. | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: mma:MM_0134 sulfopyruvate decarboxylase alpha chain. | 0.831 |
| ADI73800.1 | mtrA | Metev_0904 | Metev_2020 | KEGG: mbu:Mbur_2419 methyl-coenzyme M reductase operon protein C; TIGRFAM: methyl-coenzyme M reductase I operon protein C; PFAM: Methyl-coenzyme M reductase protein C. | Tetrahydromethanopterin S-methyltransferase, subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. | 0.936 |
| ADI73800.1 | mtrB | Metev_0904 | Metev_2019 | KEGG: mbu:Mbur_2419 methyl-coenzyme M reductase operon protein C; TIGRFAM: methyl-coenzyme M reductase I operon protein C; PFAM: Methyl-coenzyme M reductase protein C. | Tetrahydromethanopterin S-methyltransferase subunit B; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. | 0.927 |
| ADI73800.1 | mtrD | Metev_0904 | Metev_2017 | KEGG: mbu:Mbur_2419 methyl-coenzyme M reductase operon protein C; TIGRFAM: methyl-coenzyme M reductase I operon protein C; PFAM: Methyl-coenzyme M reductase protein C. | Tetrahydromethanopterin S-methyltransferase, subunit D; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. | 0.936 |
| cofC | ADI73781.1 | Metev_0264 | Metev_0883 | 2-phospho-L-lactate guanylyltransferase CofC; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: mma:MM_0134 sulfopyruvate decarboxylase alpha chain. | 0.853 |
| cofC | cofD | Metev_0264 | Metev_0504 | 2-phospho-L-lactate guanylyltransferase CofC; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. | LPPG domain protein containing protein; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | 0.997 |
| cofC | cofG | Metev_0264 | Metev_0266 | 2-phospho-L-lactate guanylyltransferase CofC; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. | 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofG subunit; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. | 0.970 |
| cofD | ADI73781.1 | Metev_0504 | Metev_0883 | LPPG domain protein containing protein; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: mma:MM_0134 sulfopyruvate decarboxylase alpha chain. | 0.825 |
| cofD | cofC | Metev_0504 | Metev_0264 | LPPG domain protein containing protein; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | 2-phospho-L-lactate guanylyltransferase CofC; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. | 0.997 |