Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
htpXPFAM: peptidase M48 Ste24p; KEGG: mbu:Mbur_1082 HtpX-2 peptidase; Belongs to the peptidase M48B family. (286 aa)    
Predicted Functional Partners:
ADI73999.1
KEGG: mma:MM_1966 malate dehydrogenase; TIGRFAM: malate dehydrogenase, NAD-dependent; PFAM: Lactate/malate dehydrogenase; Belongs to the LDH/MDH superfamily.
  
 0.891
ADI73705.1
PFAM: GHMP kinase; KEGG: mba:Mbar_A3255 pantothenate kinase.
  
    0.850
ADI73649.1
PFAM: DNA topoisomerase type IA central domain protein; TOPRIM domain protein; DNA topoisomerase type IA zn finger domain protein; KEGG: mbu:Mbur_0705 DNA topoisomerase; SMART: DNA topoisomerase I DNA-binding; DNA topoisomerase I ATP-binding; Toprim sub domain protein.
  
  
 0.753
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
  
  
 0.737
fumC
Fumarate lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 
 0.708
ADI73783.1
SMART: AAA ATPase; TIGRFAM: peptidase S16, Lon-like protease; KEGG: mbu:Mbur_0880 ATP-dependent protease Lon; PFAM: peptidase S16 lon domain protein; magnesium chelatase ChlI subunit; Belongs to the peptidase S16 family.
  
 
 0.684
ADI74304.1
KEGG: sth:STH2639 succinate dehydrogenase flavoprotein subunit; TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein.
  
  
 0.658
ilvD
TIGRFAM: dihydroxy-acid dehydratase; KEGG: mbu:Mbur_2246 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family.
  
 
 0.631
ADI74312.1
KEGG: mma:MM_1528 aconitate hydratase; TIGRFAM: aconitate hydratase 1; PFAM: aconitate hydratase domain protein.
  
 
 0.624
pgk
KEGG: mbu:Mbur_1345 phosphoglycerate kinase; PFAM: phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.
  
 
 0.601
Your Current Organism:
Methanohalobium evestigatum
NCBI taxonomy Id: 644295
Other names: M. evestigatum Z-7303, Methanohalobium evestigatum Z-7303, Methanohalobium evestigatum str. Z-7303, Methanohalobium evestigatum strain Z-7303
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