Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
polCDNA polymerase II, large subunit DP2; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. (1152 aa)    
Predicted Functional Partners:
polB
DNA-directed DNA polymerase; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family.
 
   
 0.964
thrS
KEGG: mba:Mbar_A2945 threonyl-tRNA synthetase; TIGRFAM: threonyl-tRNA synthetase; PFAM: Threonyl-tRNA synthetase editing domain protein; tRNA synthetase class II (G H P and S); Anticodon-binding domain protein; Belongs to the class-II aminoacyl-tRNA synthetase family.
  
   
 0.698
ADI74100.1
Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication.
 
   
 0.696
nac
alpha-NAC related protein; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family.
 
     0.690
pcn
Proliferating cell nuclear antigen PcnA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
 
   
 0.690
spt4
DNA-directed RNA polymerase subunit E, RpoE2; Stimulates transcription elongation; Belongs to the archaeal Spt4 family.
  
     0.665
ADI74474.1
PFAM: Protein of unknown function DUF655; KEGG: mbu:Mbur_0903 hypothetical protein.
  
     0.665
ADI72933.1
Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication.
 
   
 0.657
ADI74574.1
TIGRFAM: KH domain protein; PFAM: K Homology, type 1, subgroup; KEGG: mbu:Mbur_0948 putative RNA-processing protein; SMART: KH domain protein.
  
     0.657
ADI74813.1
PFAM: protein of unknown function DUF75; glycosyl transferase group 1; KEGG: mbu:Mbur_1398 hypothetical protein.
  
     0.653
Your Current Organism:
Methanohalobium evestigatum
NCBI taxonomy Id: 644295
Other names: M. evestigatum Z-7303, Methanohalobium evestigatum Z-7303, Methanohalobium evestigatum str. Z-7303, Methanohalobium evestigatum strain Z-7303
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