Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADI74813.1PFAM: protein of unknown function DUF75; glycosyl transferase group 1; KEGG: mbu:Mbur_1398 hypothetical protein. (256 aa)    
Predicted Functional Partners:
eif2a
Translation initiation factor 2, alpha subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family.
 
    0.938
nop10
RNA-binding protein Nop10p; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.
       0.936
ADI74814.1
PFAM: PHP domain protein; KEGG: mbu:Mbur_1399 PHP-like protein.
       0.927
rps27e
PFAM: Ribosomal protein S27E; KEGG: mma:MM_1808 30S ribosomal protein S27e.
 
     0.926
rpl44e
Ribosomal protein L44E; Binds to the 23S rRNA.
 
     0.902
priS
DNA primase, small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...]
 
     0.886
ADI74808.1
PFAM: Protein of unknown function DUF1288; KEGG: mbu:Mbur_1393 hypothetical protein.
 
     0.851
pcn
Proliferating cell nuclear antigen PcnA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
 
     0.707
polC
DNA polymerase II, large subunit DP2; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.
  
     0.653
rpl31e
PFAM: Ribosomal protein L31e; KEGG: mbu:Mbur_0114 50S ribosomal protein L31e; Belongs to the ribosomal protein L31e family.
  
     0.614
Your Current Organism:
Methanohalobium evestigatum
NCBI taxonomy Id: 644295
Other names: M. evestigatum Z-7303, Methanohalobium evestigatum Z-7303, Methanohalobium evestigatum str. Z-7303, Methanohalobium evestigatum strain Z-7303
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