Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
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gene neighborhood
gene co-occurrence
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[Homology]
Score
ADI74962.1Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (239 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
 
 0.985
ADI73230.1
KEGG: mma:MM_0307 uroporphyrin-III C-methyltransferase; TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family.
 
 
 0.946
ADI73231.1
PFAM: Uroporphyrinogen III synthase HEM4; KEGG: mac:MA3034 uroporphyrinogen-III synthase.
  
  
 
0.918
ADI73694.1
PFAM: Uroporphyrinogen decarboxylase (URO-D); KEGG: mac:MA0847 methyltransferase.
  
 
 0.912
ADI74150.1
PFAM: Uroporphyrinogen decarboxylase (URO-D); KEGG: mac:MA0847 methyltransferase.
  
 
 0.912
ADI73153.1
Porphobilinogen synthase; KEGG: mba:Mbar_A1463 delta-aminolevulinic acid dehydratase; PFAM: delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 
 0.838
ADI74963.1
KEGG: mba:Mbar_A3005 hypothetical protein.
       0.773
ADI74774.1
PFAM: sodium/hydrogen exchanger; TrkA-N domain protein; TrkA-C domain protein; KEGG: mbu:Mbur_1363 sodium/hydrogen exchanger.
  
  
 0.618
ADI74016.1
PFAM: cytochrome c biogenesis protein transmembrane region; KEGG: mac:MA1389 holocytochrome-c synthase.
  
    0.572
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.521
Your Current Organism:
Methanohalobium evestigatum
NCBI taxonomy Id: 644295
Other names: M. evestigatum Z-7303, Methanohalobium evestigatum Z-7303, Methanohalobium evestigatum str. Z-7303, Methanohalobium evestigatum strain Z-7303
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