Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
ADI74992.1Protein of unknown function DUF650; Involved in DNA damage repair; Belongs to the Nre family. (408 aa)    
Predicted Functional Partners:
ADI74993.1
KEGG: mbu:Mbur_2048 hypothetical protein.
 
     0.954
ADI74994.1
KEGG: mbu:Mbur_2049 translation initiation factor SUI1; TIGRFAM: translation initiation factor SUI1; PFAM: translation initiation factor SUI1; Belongs to the SUI1 family.
 
     0.677
ADI73444.1
PFAM: Protein of unknown function DUF424; KEGG: mma:MM_1835 hypothetical protein.
  
     0.631
ADI74607.1
Phosphate uptake regulator, PhoU; KEGG: mac:MA1380 hypothetical protein; manually curated; PFAM: PhoU family protein; SpoVT/AbrB domain protein.
 
     0.626
rps27e
PFAM: Ribosomal protein S27E; KEGG: mma:MM_1808 30S ribosomal protein S27e.
 
     0.622
ADI74100.1
Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication.
  
     0.621
ADI72933.1
Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication.
  
     0.614
dnaG
TOPRIM domain protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.
  
     0.605
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
       0.602
nac
alpha-NAC related protein; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family.
  
     0.592
Your Current Organism:
Methanohalobium evestigatum
NCBI taxonomy Id: 644295
Other names: M. evestigatum Z-7303, Methanohalobium evestigatum Z-7303, Methanohalobium evestigatum str. Z-7303, Methanohalobium evestigatum strain Z-7303
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