Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ADI74993.1KEGG: mbu:Mbur_2048 hypothetical protein. (122 aa)    
Predicted Functional Partners:
ADI74992.1
Protein of unknown function DUF650; Involved in DNA damage repair; Belongs to the Nre family.
 
     0.954
ADI74994.1
KEGG: mbu:Mbur_2049 translation initiation factor SUI1; TIGRFAM: translation initiation factor SUI1; PFAM: translation initiation factor SUI1; Belongs to the SUI1 family.
 
     0.680
iscS
Cysteine desulfurase NifS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
 
     0.623
ADI74557.1
PFAM: Protein of unknown function UPF0147; KEGG: mbu:Mbur_0922 hypothetical protein; Belongs to the UPF0147 family.
  
     0.523
ADI74173.1
KEGG: mbu:Mbur_1577 hypothetical protein.
 
     0.503
ADI74808.1
PFAM: Protein of unknown function DUF1288; KEGG: mbu:Mbur_1393 hypothetical protein.
  
     0.429
endA
tRNA intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
 
     0.425
ADI73927.1
KEGG: mbu:Mbur_1662 radical SAM family Fe-S protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB.
 
     0.419
ADI74995.1
PFAM: protein of unknown function DUF192; KEGG: mbu:Mbur_2050 hypothetical protein.
       0.410
ADI74779.1
PFAM: protein of unknown function DUF6 transmembrane; KEGG: mma:MM_2046 trimethylamine permease.
  
     0.407
Your Current Organism:
Methanohalobium evestigatum
NCBI taxonomy Id: 644295
Other names: M. evestigatum Z-7303, Methanohalobium evestigatum Z-7303, Methanohalobium evestigatum str. Z-7303, Methanohalobium evestigatum strain Z-7303
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