Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
groSChaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (90 aa)    
Predicted Functional Partners:
groL
Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
 
 
 0.998
dnaK
Chaperone protein DnaK; Acts as a chaperone.
  
 
 0.990
grpE
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
 
 0.981
ADI74274.1
Thermosome; KEGG: mac:MA1682 HSP60; TIGRFAM: thermosome; PFAM: chaperonin Cpn60/TCP-1.
 
 
 0.852
ADI74879.1
Thermosome; KEGG: mbu:Mbur_2146 thermosome, chaperonin Cpn60/TCP-1; TIGRFAM: thermosome; PFAM: chaperonin Cpn60/TCP-1.
 
 
 0.846
ADI74687.1
Thermosome; KEGG: mac:MA4413 HSP60; TIGRFAM: thermosome; PFAM: chaperonin Cpn60/TCP-1.
 
 
 0.845
ADI74546.1
PFAM: chaperonin Cpn60/TCP-1; KEGG: mac:MA0857 HSP60; Belongs to the TCP-1 chaperonin family.
 
 
 0.835
ADI75010.1
KEGG: mba:Mbar_A1541 hypothetical protein.
       0.787
ADI73440.1
TIGRFAM: biotin/acetyl-CoA-carboxylase ligase; KEGG: mba:Mbar_A1588 biotin--(acetyl-CoA-carboxylase) synthetase; PFAM: biotin/lipoate A/B protein ligase; Helix-turn-helix type 11 domain protein; biotin protein ligase domain protein.
     
 0.760
ADI73649.1
PFAM: DNA topoisomerase type IA central domain protein; TOPRIM domain protein; DNA topoisomerase type IA zn finger domain protein; KEGG: mbu:Mbur_0705 DNA topoisomerase; SMART: DNA topoisomerase I DNA-binding; DNA topoisomerase I ATP-binding; Toprim sub domain protein.
  
  
 0.737
Your Current Organism:
Methanohalobium evestigatum
NCBI taxonomy Id: 644295
Other names: M. evestigatum Z-7303, Methanohalobium evestigatum Z-7303, Methanohalobium evestigatum str. Z-7303, Methanohalobium evestigatum strain Z-7303
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.