| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADI73649.1 | ADI74056.1 | Metev_0748 | Metev_1178 | PFAM: DNA topoisomerase type IA central domain protein; TOPRIM domain protein; DNA topoisomerase type IA zn finger domain protein; KEGG: mbu:Mbur_0705 DNA topoisomerase; SMART: DNA topoisomerase I DNA-binding; DNA topoisomerase I ATP-binding; Toprim sub domain protein. | KEGG: mma:MM_3000 DNA repair helicase; PFAM: type III restriction protein res subunit; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein. | 0.889 |
| ADI73649.1 | ADI74580.1 | Metev_0748 | Metev_1742 | PFAM: DNA topoisomerase type IA central domain protein; TOPRIM domain protein; DNA topoisomerase type IA zn finger domain protein; KEGG: mbu:Mbur_0705 DNA topoisomerase; SMART: DNA topoisomerase I DNA-binding; DNA topoisomerase I ATP-binding; Toprim sub domain protein. | TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; KEGG: mbu:Mbur_1688 replicative DNA polymerase I; SMART: DNA-directed DNA polymerase B. | 0.943 |
| ADI73649.1 | ADI75035.1 | Metev_0748 | Metev_2209 | PFAM: DNA topoisomerase type IA central domain protein; TOPRIM domain protein; DNA topoisomerase type IA zn finger domain protein; KEGG: mbu:Mbur_0705 DNA topoisomerase; SMART: DNA topoisomerase I DNA-binding; DNA topoisomerase I ATP-binding; Toprim sub domain protein. | DEAD_2 domain protein; KEGG: mbu:Mbur_1566 Rad3-related DNA helicases; PFAM: DEAD_2 domain protein; SMART: helicase c2; Helicase-like, DEXD box c2 type; DEAD-like helicase. | 0.994 |
| ADI73649.1 | fen | Metev_0748 | Metev_1824 | PFAM: DNA topoisomerase type IA central domain protein; TOPRIM domain protein; DNA topoisomerase type IA zn finger domain protein; KEGG: mbu:Mbur_0705 DNA topoisomerase; SMART: DNA topoisomerase I DNA-binding; DNA topoisomerase I ATP-binding; Toprim sub domain protein. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.991 |
| ADI73649.1 | pcn | Metev_0748 | Metev_1124 | PFAM: DNA topoisomerase type IA central domain protein; TOPRIM domain protein; DNA topoisomerase type IA zn finger domain protein; KEGG: mbu:Mbur_0705 DNA topoisomerase; SMART: DNA topoisomerase I DNA-binding; DNA topoisomerase I ATP-binding; Toprim sub domain protein. | Proliferating cell nuclear antigen PcnA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.992 |
| ADI73649.1 | rpoD | Metev_0748 | Metev_0827 | PFAM: DNA topoisomerase type IA central domain protein; TOPRIM domain protein; DNA topoisomerase type IA zn finger domain protein; KEGG: mbu:Mbur_0705 DNA topoisomerase; SMART: DNA topoisomerase I DNA-binding; DNA topoisomerase I ATP-binding; Toprim sub domain protein. | DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.998 |
| ADI73649.1 | rpoH | Metev_0748 | Metev_0784 | PFAM: DNA topoisomerase type IA central domain protein; TOPRIM domain protein; DNA topoisomerase type IA zn finger domain protein; KEGG: mbu:Mbur_0705 DNA topoisomerase; SMART: DNA topoisomerase I DNA-binding; DNA topoisomerase I ATP-binding; Toprim sub domain protein. | RNA polymerase Rpb5; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. | 0.912 |
| ADI73649.1 | rpoN | Metev_0748 | Metev_0317 | PFAM: DNA topoisomerase type IA central domain protein; TOPRIM domain protein; DNA topoisomerase type IA zn finger domain protein; KEGG: mbu:Mbur_0705 DNA topoisomerase; SMART: DNA topoisomerase I DNA-binding; DNA topoisomerase I ATP-binding; Toprim sub domain protein. | RNA polymerase, N/8 Kd subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family. | 0.900 |
| ADI73649.1 | rpoP | Metev_0748 | Metev_0596 | PFAM: DNA topoisomerase type IA central domain protein; TOPRIM domain protein; DNA topoisomerase type IA zn finger domain protein; KEGG: mbu:Mbur_0705 DNA topoisomerase; SMART: DNA topoisomerase I DNA-binding; DNA topoisomerase I ATP-binding; Toprim sub domain protein. | RNA polymerase Rbp10; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family. | 0.902 |
| ADI73649.1 | tfe | Metev_0748 | Metev_0416 | PFAM: DNA topoisomerase type IA central domain protein; TOPRIM domain protein; DNA topoisomerase type IA zn finger domain protein; KEGG: mbu:Mbur_0705 DNA topoisomerase; SMART: DNA topoisomerase I DNA-binding; DNA topoisomerase I ATP-binding; Toprim sub domain protein. | Transcription factor TFIIE, alpha subunit; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongatio [...] | 0.887 |
| ADI74056.1 | ADI73649.1 | Metev_1178 | Metev_0748 | KEGG: mma:MM_3000 DNA repair helicase; PFAM: type III restriction protein res subunit; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein. | PFAM: DNA topoisomerase type IA central domain protein; TOPRIM domain protein; DNA topoisomerase type IA zn finger domain protein; KEGG: mbu:Mbur_0705 DNA topoisomerase; SMART: DNA topoisomerase I DNA-binding; DNA topoisomerase I ATP-binding; Toprim sub domain protein. | 0.889 |
| ADI74056.1 | ADI74580.1 | Metev_1178 | Metev_1742 | KEGG: mma:MM_3000 DNA repair helicase; PFAM: type III restriction protein res subunit; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein. | TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; KEGG: mbu:Mbur_1688 replicative DNA polymerase I; SMART: DNA-directed DNA polymerase B. | 0.784 |
| ADI74056.1 | ADI75035.1 | Metev_1178 | Metev_2209 | KEGG: mma:MM_3000 DNA repair helicase; PFAM: type III restriction protein res subunit; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein. | DEAD_2 domain protein; KEGG: mbu:Mbur_1566 Rad3-related DNA helicases; PFAM: DEAD_2 domain protein; SMART: helicase c2; Helicase-like, DEXD box c2 type; DEAD-like helicase. | 0.976 |
| ADI74056.1 | fen | Metev_1178 | Metev_1824 | KEGG: mma:MM_3000 DNA repair helicase; PFAM: type III restriction protein res subunit; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.967 |
| ADI74056.1 | pcn | Metev_1178 | Metev_1124 | KEGG: mma:MM_3000 DNA repair helicase; PFAM: type III restriction protein res subunit; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein. | Proliferating cell nuclear antigen PcnA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.797 |
| ADI74056.1 | rpoD | Metev_1178 | Metev_0827 | KEGG: mma:MM_3000 DNA repair helicase; PFAM: type III restriction protein res subunit; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein. | DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.952 |
| ADI74056.1 | rpoH | Metev_1178 | Metev_0784 | KEGG: mma:MM_3000 DNA repair helicase; PFAM: type III restriction protein res subunit; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein. | RNA polymerase Rpb5; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. | 0.953 |
| ADI74056.1 | rpoN | Metev_1178 | Metev_0317 | KEGG: mma:MM_3000 DNA repair helicase; PFAM: type III restriction protein res subunit; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein. | RNA polymerase, N/8 Kd subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family. | 0.935 |
| ADI74056.1 | rpoP | Metev_1178 | Metev_0596 | KEGG: mma:MM_3000 DNA repair helicase; PFAM: type III restriction protein res subunit; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein. | RNA polymerase Rbp10; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family. | 0.935 |
| ADI74056.1 | tfe | Metev_1178 | Metev_0416 | KEGG: mma:MM_3000 DNA repair helicase; PFAM: type III restriction protein res subunit; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein. | Transcription factor TFIIE, alpha subunit; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongatio [...] | 0.967 |