Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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ADI75055.1PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; KEGG: mbu:Mbur_0174 acetolactate synthase, large subunit; Belongs to the TPP enzyme family. (545 aa)    
Predicted Functional Partners:
ADI73646.1
TIGRFAM: acetolactate synthase, small subunit; KEGG: mac:MA3791 acetolactate synthase 3 regulatory subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein.
  
  
  0.915
ADI73645.1
KEGG: mba:Mbar_A0218 acetolactate synthase 3 catalytic subunit; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding.
  
  
 
0.911
ADI73014.1
KEGG: mma:MM_1489 3-isopropylmalate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase.
     
  0.900
cimA
Isopropylmalate/citramalate/homocitrate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family.
     
  0.900
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
     
  0.900
ADI74480.1
TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit; KEGG: mbu:Mbur_0889 2-oxoglutarate ferredoxin oxidoreductase subunit beta; PFAM: thiamine pyrophosphate protein domain protein TPP-binding.
     
  0.900
ADI74481.1
PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase; KEGG: mbu:Mbur_0890 pyruvate flavodoxin/ferredoxin oxidoreductase-like protein.
     
  0.900
ADI74667.1
PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: mma:MM_1339 pyruvate synthase beta subunit.
     
  0.900
ADI74668.1
PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Transketolase domain protein; KEGG: mbu:Mbur_2157 pyruvate ferredoxin oxidoreductase, alpha subunit.
     
  0.900
ADI74669.1
KEGG: mbu:Mbur_2156 pyruvate ferredoxin oxidoreductase, delta subunit; TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein.
     
  0.900
Your Current Organism:
Methanohalobium evestigatum
NCBI taxonomy Id: 644295
Other names: M. evestigatum Z-7303, Methanohalobium evestigatum Z-7303, Methanohalobium evestigatum str. Z-7303, Methanohalobium evestigatum strain Z-7303
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