| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cbiE/cbiT | nadE | sync_0810 | sync_2294 | Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE/T subunits; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR02467; match to protein family HMM TIGR02469. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.472 |
| cbiE/cbiT | nrdR | sync_0810 | sync_0532 | Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE/T subunits; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR02467; match to protein family HMM TIGR02469. | Transcriptional regulator, NrdR family protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.551 |
| cbiE/cbiT | ribD | sync_0810 | sync_0821 | Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE/T subunits; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR02467; match to protein family HMM TIGR02469. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.517 |
| gph | metK | sync_0530 | sync_0529 | Haloacid dehalogenase/epoxide hydrolase family protein; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.722 |
| gph | nrdR | sync_0530 | sync_0532 | Haloacid dehalogenase/epoxide hydrolase family protein; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549. | Transcriptional regulator, NrdR family protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.503 |
| gph | ribAB | sync_0530 | sync_1383 | Haloacid dehalogenase/epoxide hydrolase family protein; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549. | Riboflavin biosynthesis protein RibA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.464 |
| gph | rpsA | sync_0530 | sync_0531 | Haloacid dehalogenase/epoxide hydrolase family protein; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549. | Ribosomal protein S1; Identified by similarity to SP:P46228; match to protein family HMM PF00575. | 0.802 |
| gph | sync_0528 | sync_0530 | sync_0528 | Haloacid dehalogenase/epoxide hydrolase family protein; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549. | Carbohydrate kinase, FGGY family protein; Identified by match to protein family HMM PF00370. | 0.709 |
| metK | gph | sync_0529 | sync_0530 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Haloacid dehalogenase/epoxide hydrolase family protein; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549. | 0.722 |
| metK | nrdR | sync_0529 | sync_0532 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Transcriptional regulator, NrdR family protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.462 |
| metK | ribAB | sync_0529 | sync_1383 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Riboflavin biosynthesis protein RibA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.681 |
| metK | ribD | sync_0529 | sync_0821 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.669 |
| metK | rpsA | sync_0529 | sync_0531 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Ribosomal protein S1; Identified by similarity to SP:P46228; match to protein family HMM PF00575. | 0.741 |
| metK | sync_0528 | sync_0529 | sync_0528 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Carbohydrate kinase, FGGY family protein; Identified by match to protein family HMM PF00370. | 0.826 |
| nadE | cbiE/cbiT | sync_2294 | sync_0810 | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE/T subunits; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR02467; match to protein family HMM TIGR02469. | 0.472 |
| nadE | nrdR | sync_2294 | sync_0532 | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | Transcriptional regulator, NrdR family protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.562 |
| nadE | ribAB | sync_2294 | sync_1383 | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | Riboflavin biosynthesis protein RibA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.683 |
| nadE | ribD | sync_2294 | sync_0821 | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.685 |
| nrdR | cbiE/cbiT | sync_0532 | sync_0810 | Transcriptional regulator, NrdR family protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE/T subunits; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR02467; match to protein family HMM TIGR02469. | 0.551 |
| nrdR | gph | sync_0532 | sync_0530 | Transcriptional regulator, NrdR family protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | Haloacid dehalogenase/epoxide hydrolase family protein; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549. | 0.503 |