| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| guaA | hflX | sync_0047 | sync_2512 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | GTP-binding protein HflX homolog; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. | 0.424 |
| guaA | metH | sync_0047 | sync_1353 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.673 |
| guaA | metK | sync_0047 | sync_0529 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.707 |
| guaA | nadE | sync_0047 | sync_2294 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.763 |
| guaA | pheT | sync_0047 | sync_1339 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | phenylalanyl-tRNA synthetase, beta subunit; Identified by match to protein family HMM PF01588; match to protein family HMM PF03147; match to protein family HMM PF03483; match to protein family HMM PF03484; match to protein family HMM TIGR00472; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.938 |
| guaA | sync_0156 | sync_0047 | sync_0156 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Polyketide synthase, putative; Identified by match to protein family HMM PF00106; match to protein family HMM PF00107; match to protein family HMM PF00109; match to protein family HMM PF00550; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02801; match to protein family HMM PF07993; match to protein family HMM TIGR01746. | 0.753 |
| guaA | sync_0834 | sync_0047 | sync_0834 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Conserved hypothetical protein. | 0.481 |
| guaA | sync_2911 | sync_0047 | sync_2911 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Chloride transporter, chloride channel (ClC) family protein; Identified by match to protein family HMM PF00654. | 0.863 |
| hflX | guaA | sync_2512 | sync_0047 | GTP-binding protein HflX homolog; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | 0.424 |
| hflX | pheT | sync_2512 | sync_1339 | GTP-binding protein HflX homolog; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. | phenylalanyl-tRNA synthetase, beta subunit; Identified by match to protein family HMM PF01588; match to protein family HMM PF03147; match to protein family HMM PF03483; match to protein family HMM PF03484; match to protein family HMM TIGR00472; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.425 |
| hflX | sync_0156 | sync_2512 | sync_0156 | GTP-binding protein HflX homolog; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. | Polyketide synthase, putative; Identified by match to protein family HMM PF00106; match to protein family HMM PF00107; match to protein family HMM PF00109; match to protein family HMM PF00550; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02801; match to protein family HMM PF07993; match to protein family HMM TIGR01746. | 0.912 |
| hflX | sync_0834 | sync_2512 | sync_0834 | GTP-binding protein HflX homolog; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. | Conserved hypothetical protein. | 0.415 |
| hflX | sync_2911 | sync_2512 | sync_2911 | GTP-binding protein HflX homolog; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. | Chloride transporter, chloride channel (ClC) family protein; Identified by match to protein family HMM PF00654. | 0.569 |
| metH | guaA | sync_1353 | sync_0047 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | 0.673 |
| metH | metK | sync_1353 | sync_0529 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.961 |
| metH | sync_0156 | sync_1353 | sync_0156 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Polyketide synthase, putative; Identified by match to protein family HMM PF00106; match to protein family HMM PF00107; match to protein family HMM PF00109; match to protein family HMM PF00550; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02801; match to protein family HMM PF07993; match to protein family HMM TIGR01746. | 0.501 |
| metH | sync_0834 | sync_1353 | sync_0834 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Conserved hypothetical protein. | 0.561 |
| metH | sync_2911 | sync_1353 | sync_2911 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Chloride transporter, chloride channel (ClC) family protein; Identified by match to protein family HMM PF00654. | 0.506 |
| metK | guaA | sync_0529 | sync_0047 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | 0.707 |
| metK | metH | sync_0529 | sync_1353 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.961 |