| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| guaA | panC/cmk | sync_0047 | sync_0483 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Pantoate--beta-alanine ligase/cytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily. | 0.744 |
| guaA | purA | sync_0047 | sync_2023 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.890 |
| guaA | purH | sync_0047 | sync_0289 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Bifunctional purine biosynthesis protein PurH; Identified by match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. | 0.939 |
| guaA | rdgB | sync_0047 | sync_0272 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.954 |
| guaA | surE | sync_0047 | sync_0795 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.965 |
| guaA | sync_0156 | sync_0047 | sync_0156 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Polyketide synthase, putative; Identified by match to protein family HMM PF00106; match to protein family HMM PF00107; match to protein family HMM PF00109; match to protein family HMM PF00550; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02801; match to protein family HMM PF07993; match to protein family HMM TIGR01746. | 0.738 |
| guaA | sync_0971 | sync_0047 | sync_0971 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Identified by match to protein family HMM PF00478; match to protein family HMM TIGR01304. | 0.985 |
| guaA | sync_1158 | sync_0047 | sync_1158 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Possible phosphoribosyltransferase family protein. | 0.900 |
| guaA | sync_2880 | sync_0047 | sync_2880 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Glutamine amidotransferase, class I; Identified by match to protein family HMM PF00117. | 0.906 |
| panC/cmk | guaA | sync_0483 | sync_0047 | Pantoate--beta-alanine ligase/cytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily. | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | 0.744 |
| panC/cmk | surE | sync_0483 | sync_0795 | Pantoate--beta-alanine ligase/cytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily. | Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.943 |
| panC/cmk | sync_0156 | sync_0483 | sync_0156 | Pantoate--beta-alanine ligase/cytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily. | Polyketide synthase, putative; Identified by match to protein family HMM PF00106; match to protein family HMM PF00107; match to protein family HMM PF00109; match to protein family HMM PF00550; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02801; match to protein family HMM PF07993; match to protein family HMM TIGR01746. | 0.701 |
| panC/cmk | sync_0971 | sync_0483 | sync_0971 | Pantoate--beta-alanine ligase/cytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily. | Identified by match to protein family HMM PF00478; match to protein family HMM TIGR01304. | 0.633 |
| panC/cmk | sync_2880 | sync_0483 | sync_2880 | Pantoate--beta-alanine ligase/cytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily. | Glutamine amidotransferase, class I; Identified by match to protein family HMM PF00117. | 0.531 |
| purA | guaA | sync_2023 | sync_0047 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | 0.890 |
| purA | purH | sync_2023 | sync_0289 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Bifunctional purine biosynthesis protein PurH; Identified by match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. | 0.984 |
| purA | rdgB | sync_2023 | sync_0272 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.928 |
| purA | surE | sync_2023 | sync_0795 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.904 |
| purA | sync_0156 | sync_2023 | sync_0156 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Polyketide synthase, putative; Identified by match to protein family HMM PF00106; match to protein family HMM PF00107; match to protein family HMM PF00109; match to protein family HMM PF00550; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02801; match to protein family HMM PF07993; match to protein family HMM TIGR01746. | 0.435 |
| purA | sync_0971 | sync_2023 | sync_0971 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Identified by match to protein family HMM PF00478; match to protein family HMM TIGR01304. | 0.932 |