| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| gmk | guaA | sync_2153 | sync_0047 | Guanylate kinase, putative; Essential for recycling GMP and indirectly, cGMP. | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | 0.969 |
| gmk | surE | sync_2153 | sync_0795 | Guanylate kinase, putative; Essential for recycling GMP and indirectly, cGMP. | Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
| gmk | sync_1158 | sync_2153 | sync_1158 | Guanylate kinase, putative; Essential for recycling GMP and indirectly, cGMP. | Possible phosphoribosyltransferase family protein. | 0.900 |
| gmk | sync_2880 | sync_2153 | sync_2880 | Guanylate kinase, putative; Essential for recycling GMP and indirectly, cGMP. | Glutamine amidotransferase, class I; Identified by match to protein family HMM PF00117. | 0.917 |
| guaA | gmk | sync_0047 | sync_2153 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Guanylate kinase, putative; Essential for recycling GMP and indirectly, cGMP. | 0.969 |
| guaA | rdgB | sync_0047 | sync_0272 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.954 |
| guaA | surE | sync_0047 | sync_0795 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.965 |
| guaA | sync_0971 | sync_0047 | sync_0971 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Identified by match to protein family HMM PF00478; match to protein family HMM TIGR01304. | 0.985 |
| guaA | sync_1158 | sync_0047 | sync_1158 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Possible phosphoribosyltransferase family protein. | 0.900 |
| guaA | sync_2880 | sync_0047 | sync_2880 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Glutamine amidotransferase, class I; Identified by match to protein family HMM PF00117. | 0.906 |
| rdgB | guaA | sync_0272 | sync_0047 | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | 0.954 |
| rdgB | surE | sync_0272 | sync_0795 | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
| rdgB | sync_0971 | sync_0272 | sync_0971 | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Identified by match to protein family HMM PF00478; match to protein family HMM TIGR01304. | 0.919 |
| rdgB | sync_1158 | sync_0272 | sync_1158 | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Possible phosphoribosyltransferase family protein. | 0.900 |
| rdgB | sync_2880 | sync_0272 | sync_2880 | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamine amidotransferase, class I; Identified by match to protein family HMM PF00117. | 0.902 |
| surE | gmk | sync_0795 | sync_2153 | Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | Guanylate kinase, putative; Essential for recycling GMP and indirectly, cGMP. | 0.900 |
| surE | guaA | sync_0795 | sync_0047 | Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | 0.965 |
| surE | rdgB | sync_0795 | sync_0272 | Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.900 |
| surE | sync_0971 | sync_0795 | sync_0971 | Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | Identified by match to protein family HMM PF00478; match to protein family HMM TIGR01304. | 0.902 |
| surE | sync_1158 | sync_0795 | sync_1158 | Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | Possible phosphoribosyltransferase family protein. | 0.900 |