| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| grpE-1 | htpG | sync_0022 | sync_1398 | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | Chaperone protein HtpG; Identified by similarity to SP:Q9S3Q2; match to protein family HMM PF00183; match to protein family HMM PF02518. | 0.833 |
| grpE-1 | sync_0156 | sync_0022 | sync_0156 | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | Polyketide synthase, putative; Identified by match to protein family HMM PF00106; match to protein family HMM PF00107; match to protein family HMM PF00109; match to protein family HMM PF00550; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02801; match to protein family HMM PF07993; match to protein family HMM TIGR01746. | 0.646 |
| grpE-1 | sync_1452 | sync_0022 | sync_1452 | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | DnaJ domain-containing protein; Identified by match to protein family HMM PF00226. | 0.689 |
| htpG | grpE-1 | sync_1398 | sync_0022 | Chaperone protein HtpG; Identified by similarity to SP:Q9S3Q2; match to protein family HMM PF00183; match to protein family HMM PF02518. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.833 |
| htpG | sync_0156 | sync_1398 | sync_0156 | Chaperone protein HtpG; Identified by similarity to SP:Q9S3Q2; match to protein family HMM PF00183; match to protein family HMM PF02518. | Polyketide synthase, putative; Identified by match to protein family HMM PF00106; match to protein family HMM PF00107; match to protein family HMM PF00109; match to protein family HMM PF00550; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02801; match to protein family HMM PF07993; match to protein family HMM TIGR01746. | 0.808 |
| htpG | sync_1452 | sync_1398 | sync_1452 | Chaperone protein HtpG; Identified by similarity to SP:Q9S3Q2; match to protein family HMM PF00183; match to protein family HMM PF02518. | DnaJ domain-containing protein; Identified by match to protein family HMM PF00226. | 0.776 |
| rplC | rplK | sync_0437 | sync_2727 | Ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | 0.998 |
| rplC | rplM | sync_0437 | sync_0411 | Ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | Ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | 0.999 |
| rplC | rplN | sync_0437 | sync_0427 | Ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | Ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. | 0.999 |
| rplC | rplO | sync_0437 | sync_0420 | Ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | Ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. | 0.999 |
| rplC | rplQ | sync_0437 | sync_0413 | Ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | Ribosomal protein L17; Identified by match to protein family HMM PF01196; match to protein family HMM TIGR00059. | 0.997 |
| rplC | sync_0156 | sync_0437 | sync_0156 | Ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | Polyketide synthase, putative; Identified by match to protein family HMM PF00106; match to protein family HMM PF00107; match to protein family HMM PF00109; match to protein family HMM PF00550; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02801; match to protein family HMM PF07993; match to protein family HMM TIGR01746. | 0.850 |
| rplC | sync_1452 | sync_0437 | sync_1452 | Ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | DnaJ domain-containing protein; Identified by match to protein family HMM PF00226. | 0.622 |
| rplC | trmE | sync_0437 | sync_2699 | Ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | tRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | 0.719 |
| rplK | rplC | sync_2727 | sync_0437 | Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | Ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | 0.998 |
| rplK | rplM | sync_2727 | sync_0411 | Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | Ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | 0.996 |
| rplK | rplN | sync_2727 | sync_0427 | Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | Ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. | 0.997 |
| rplK | rplO | sync_2727 | sync_0420 | Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | Ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. | 0.995 |
| rplK | rplQ | sync_2727 | sync_0413 | Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | Ribosomal protein L17; Identified by match to protein family HMM PF01196; match to protein family HMM TIGR00059. | 0.995 |
| rplK | sync_0156 | sync_2727 | sync_0156 | Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | Polyketide synthase, putative; Identified by match to protein family HMM PF00106; match to protein family HMM PF00107; match to protein family HMM PF00109; match to protein family HMM PF00550; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02801; match to protein family HMM PF07993; match to protein family HMM TIGR01746. | 0.877 |
STRING v12.5 is now available!
