| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| apt | gmk | sync_1226 | sync_2153 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase, putative; Essential for recycling GMP and indirectly, cGMP. | 0.956 |
| apt | guaA | sync_1226 | sync_0047 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | 0.995 |
| apt | surE | sync_1226 | sync_0795 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.917 |
| apt | sync_1158 | sync_1226 | sync_1158 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Possible phosphoribosyltransferase family protein. | 0.900 |
| apt | sync_2880 | sync_1226 | sync_2880 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Glutamine amidotransferase, class I; Identified by match to protein family HMM PF00117. | 0.929 |
| gmk | apt | sync_2153 | sync_1226 | Guanylate kinase, putative; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.956 |
| gmk | guaA | sync_2153 | sync_0047 | Guanylate kinase, putative; Essential for recycling GMP and indirectly, cGMP. | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | 0.960 |
| gmk | ndk | sync_2153 | sync_2741 | Guanylate kinase, putative; Essential for recycling GMP and indirectly, cGMP. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.932 |
| gmk | pyk | sync_2153 | sync_1415 | Guanylate kinase, putative; Essential for recycling GMP and indirectly, cGMP. | Pyruvate kinase; Identified by match to protein family HMM PF00224; match to protein family HMM PF00391; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. | 0.948 |
| gmk | rpoZ | sync_2153 | sync_2269 | Guanylate kinase, putative; Essential for recycling GMP and indirectly, cGMP. | Putative DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.941 |
| gmk | surE | sync_2153 | sync_0795 | Guanylate kinase, putative; Essential for recycling GMP and indirectly, cGMP. | Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
| gmk | sync_1158 | sync_2153 | sync_1158 | Guanylate kinase, putative; Essential for recycling GMP and indirectly, cGMP. | Possible phosphoribosyltransferase family protein. | 0.900 |
| gmk | sync_1265 | sync_2153 | sync_1265 | Guanylate kinase, putative; Essential for recycling GMP and indirectly, cGMP. | Ribonucleotide reductase (Class II); Identified by match to protein family HMM TIGR02505. | 0.900 |
| gmk | sync_2702 | sync_2153 | sync_2702 | Guanylate kinase, putative; Essential for recycling GMP and indirectly, cGMP. | RelA/SpoT family protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.929 |
| gmk | sync_2880 | sync_2153 | sync_2880 | Guanylate kinase, putative; Essential for recycling GMP and indirectly, cGMP. | Glutamine amidotransferase, class I; Identified by match to protein family HMM PF00117. | 0.916 |
| guaA | apt | sync_0047 | sync_1226 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.995 |
| guaA | gmk | sync_0047 | sync_2153 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Guanylate kinase, putative; Essential for recycling GMP and indirectly, cGMP. | 0.960 |
| guaA | ndk | sync_0047 | sync_2741 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.729 |
| guaA | pyk | sync_0047 | sync_1415 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Pyruvate kinase; Identified by match to protein family HMM PF00224; match to protein family HMM PF00391; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. | 0.647 |
| guaA | surE | sync_0047 | sync_0795 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.968 |