| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| coaBC | coaD | sync_0352 | sync_1362 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.945 |
| coaBC | panC/cmk | sync_0352 | sync_0483 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantoate--beta-alanine ligase/cytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily. | 0.911 |
| coaBC | sync_2509 | sync_0352 | sync_2509 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Transcriptional activator, putative, Baf family protein; Identified by match to protein family HMM TIGR00671. | 0.926 |
| coaD | coaBC | sync_1362 | sync_0352 | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.945 |
| coaD | panC/cmk | sync_1362 | sync_0483 | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Pantoate--beta-alanine ligase/cytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily. | 0.660 |
| coaD | sync_2509 | sync_1362 | sync_2509 | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Transcriptional activator, putative, Baf family protein; Identified by match to protein family HMM TIGR00671. | 0.930 |
| hflX | sync_2509 | sync_2512 | sync_2509 | GTP-binding protein HflX homolog; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. | Transcriptional activator, putative, Baf family protein; Identified by match to protein family HMM TIGR00671. | 0.644 |
| hflX | sync_2510 | sync_2512 | sync_2510 | GTP-binding protein HflX homolog; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | 0.689 |
| hflX | sync_2511 | sync_2512 | sync_2511 | GTP-binding protein HflX homolog; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. | NADH dehydrogenase, FAD-containing subunit; Identified by match to protein family HMM PF00070; match to protein family HMM PF07992. | 0.793 |
| hflX | sync_2514 | sync_2512 | sync_2514 | GTP-binding protein HflX homolog; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. | Possible sodium transporter, Trk family protein; Identified by match to protein family HMM PF02386. | 0.584 |
| ilvC | sync_2509 | sync_0725 | sync_2509 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Transcriptional activator, putative, Baf family protein; Identified by match to protein family HMM TIGR00671. | 0.555 |
| panC/cmk | coaBC | sync_0483 | sync_0352 | Pantoate--beta-alanine ligase/cytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily. | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.911 |
| panC/cmk | coaD | sync_0483 | sync_1362 | Pantoate--beta-alanine ligase/cytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily. | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.660 |
| panC/cmk | sync_2109 | sync_0483 | sync_2109 | Pantoate--beta-alanine ligase/cytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily. | biotin--acetyl-CoA-carboxylase ligase; Identified by match to protein family HMM PF03099; match to protein family HMM TIGR00121. | 0.470 |
| panC/cmk | sync_2509 | sync_0483 | sync_2509 | Pantoate--beta-alanine ligase/cytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily. | Transcriptional activator, putative, Baf family protein; Identified by match to protein family HMM TIGR00671. | 0.969 |
| panC/cmk | tmk | sync_0483 | sync_2593 | Pantoate--beta-alanine ligase/cytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.605 |
| sync_2109 | panC/cmk | sync_2109 | sync_0483 | biotin--acetyl-CoA-carboxylase ligase; Identified by match to protein family HMM PF03099; match to protein family HMM TIGR00121. | Pantoate--beta-alanine ligase/cytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily. | 0.470 |
| sync_2109 | sync_2509 | sync_2109 | sync_2509 | biotin--acetyl-CoA-carboxylase ligase; Identified by match to protein family HMM PF03099; match to protein family HMM TIGR00121. | Transcriptional activator, putative, Baf family protein; Identified by match to protein family HMM TIGR00671. | 0.505 |
| sync_2509 | coaBC | sync_2509 | sync_0352 | Transcriptional activator, putative, Baf family protein; Identified by match to protein family HMM TIGR00671. | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.926 |
| sync_2509 | coaD | sync_2509 | sync_1362 | Transcriptional activator, putative, Baf family protein; Identified by match to protein family HMM TIGR00671. | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.930 |