thrC protein (Synechococcus sp. CC9311) - STRING interaction network

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thrC

Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (352 aa)

Predicted Functional Partners:

thrB

0.994

ilvA

0.970

hom

0.957

pdxA

0.901

sync_0075

0.846

leuD

0.796

sync_2944

0.773

ilvC

0.757

sync_0387

0.742

hisIE

0.672

Your Current Organism:

Synechococcus sp. CC9311

NCBI taxonomy Id: 64471
Other names: S. sp. CC9311

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
hisIE	hom	sync_1899	sync_0941	Histidine biosynthesis bifunctional protein HisIE; Identified by similarity to SP:O34912; match to protein family HMM PF01502; match to protein family HMM PF01503; In the N-terminal section; belongs to the PRA-CH family.	Homoserine dehydrogenase; Identified by match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447.	0.459
hisIE	ilvA	sync_1899	sync_1411	Histidine biosynthesis bifunctional protein HisIE; Identified by similarity to SP:O34912; match to protein family HMM PF01502; match to protein family HMM PF01503; In the N-terminal section; belongs to the PRA-CH family.	Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.	0.603
hisIE	ilvC	sync_1899	sync_0725	Histidine biosynthesis bifunctional protein HisIE; Identified by similarity to SP:O34912; match to protein family HMM PF01502; match to protein family HMM PF01503; In the N-terminal section; belongs to the PRA-CH family.	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.	0.500
hisIE	leuD	sync_1899	sync_0304	Histidine biosynthesis bifunctional protein HisIE; Identified by similarity to SP:O34912; match to protein family HMM PF01502; match to protein family HMM PF01503; In the N-terminal section; belongs to the PRA-CH family.	3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.	0.464
hisIE	sync_0075	sync_1899	sync_0075	Histidine biosynthesis bifunctional protein HisIE; Identified by similarity to SP:O34912; match to protein family HMM PF01502; match to protein family HMM PF01503; In the N-terminal section; belongs to the PRA-CH family.	Asparate kinase, monofunctional class; Identified by similarity to SP:P08495; match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM TIGR00656; match to protein family HMM TIGR00657.	0.695
hisIE	sync_0387	sync_1899	sync_0387	Histidine biosynthesis bifunctional protein HisIE; Identified by similarity to SP:O34912; match to protein family HMM PF01502; match to protein family HMM PF01503; In the N-terminal section; belongs to the PRA-CH family.	Ferredoxin-dependent glutamate synthase, Fd-GOGAT; Identified by match to protein family HMM PF00310; match to protein family HMM PF00478; match to protein family HMM PF01493; match to protein family HMM PF01645; match to protein family HMM PF04898.	0.691
hisIE	thrC	sync_1899	sync_2943	Histidine biosynthesis bifunctional protein HisIE; Identified by similarity to SP:O34912; match to protein family HMM PF01502; match to protein family HMM PF01503; In the N-terminal section; belongs to the PRA-CH family.	Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.	0.672
hom	hisIE	sync_0941	sync_1899	Homoserine dehydrogenase; Identified by match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447.	Histidine biosynthesis bifunctional protein HisIE; Identified by similarity to SP:O34912; match to protein family HMM PF01502; match to protein family HMM PF01503; In the N-terminal section; belongs to the PRA-CH family.	0.459
hom	ilvA	sync_0941	sync_1411	Homoserine dehydrogenase; Identified by match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447.	Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.	0.406
hom	sync_0075	sync_0941	sync_0075	Homoserine dehydrogenase; Identified by match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447.	Asparate kinase, monofunctional class; Identified by similarity to SP:P08495; match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM TIGR00656; match to protein family HMM TIGR00657.	0.933
hom	sync_0387	sync_0941	sync_0387	Homoserine dehydrogenase; Identified by match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447.	Ferredoxin-dependent glutamate synthase, Fd-GOGAT; Identified by match to protein family HMM PF00310; match to protein family HMM PF00478; match to protein family HMM PF01493; match to protein family HMM PF01645; match to protein family HMM PF04898.	0.698
hom	thrB	sync_0941	sync_1869	Homoserine dehydrogenase; Identified by match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447.	Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.	0.993
hom	thrC	sync_0941	sync_2943	Homoserine dehydrogenase; Identified by match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447.	Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.	0.957
ilvA	hisIE	sync_1411	sync_1899	Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.	Histidine biosynthesis bifunctional protein HisIE; Identified by similarity to SP:O34912; match to protein family HMM PF01502; match to protein family HMM PF01503; In the N-terminal section; belongs to the PRA-CH family.	0.603
ilvA	hom	sync_1411	sync_0941	Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.	Homoserine dehydrogenase; Identified by match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447.	0.406
ilvA	ilvC	sync_1411	sync_0725	Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.	0.780
ilvA	leuD	sync_1411	sync_0304	Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.	3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.	0.458
ilvA	sync_0075	sync_1411	sync_0075	Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.	Asparate kinase, monofunctional class; Identified by similarity to SP:P08495; match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM TIGR00656; match to protein family HMM TIGR00657.	0.435
ilvA	sync_0387	sync_1411	sync_0387	Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.	Ferredoxin-dependent glutamate synthase, Fd-GOGAT; Identified by match to protein family HMM PF00310; match to protein family HMM PF00478; match to protein family HMM PF01493; match to protein family HMM PF01645; match to protein family HMM PF04898.	0.713
ilvA	thrB	sync_1411	sync_1869	Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.	Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.	0.402