Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
kuKu protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (293 aa)    
Predicted Functional Partners:
AGA86713.1
ATP-dependent DNA ligase LigD polymerase module; PFAM: ATP dependent DNA ligase domain; Eukaryotic and archaeal DNA primase small subunit; ATP dependent DNA ligase C terminal region; TIGRFAM: DNA polymerase LigD, ligase domain; DNA ligase D; DNA ligase D, 3'-phosphoesterase domain; DNA polymerase LigD, polymerase domain; ATP-dependent DNA ligase LigD phosphoesterase module.
 
  
 0.987
AGA86684.1
DNA polymerase LigD, polymerase domain protein; PFAM: Eukaryotic and archaeal DNA primase small subunit; TIGRFAM: DNA ligase D; DNA polymerase LigD, polymerase domain.
 
  
 0.986
AGA86682.1
Dehydrogenase of unknown specificity, short-chain alcohol dehydrogenase like protein; PFAM: short chain dehydrogenase.
 
    0.783
AGA86641.1
Topoisomerase IB; PFAM: Eukaryotic DNA topoisomerase I, catalytic core.
 
    0.624
AGA86198.1
PFAM: ATP dependent DNA ligase domain; DNA ligase N terminus; ATP dependent DNA ligase C terminal region.
 
  
 0.597
AGA86696.1
PFAM: Protein of unknown function DUF72.
 
    0.571
AGA86681.1
Zn-dependent oxidoreductase, NADPH:quinone reductase; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase.
       0.442
AGA87602.1
Putative outer membrane protein.
 
    0.414
Your Current Organism:
Pseudomonas stutzeri
NCBI taxonomy Id: 644801
Other names: P. stutzeri RCH2, Pseudomonas stutzeri RCH2, Pseudomonas stutzeri str. RCH2, Pseudomonas stutzeri strain RCH2
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