STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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[Homology]
Score
Tmar_0002DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (369 aa)    
Predicted Functional Partners:
dnaA
Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family.
 
 0.997
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
 
 0.993
Tmar_0072
COGs: COG2812 DNA polymerase III gamma/tau subunits; InterPro IPR003593: IPR003959: IPR012763: IPR001270; KEGG: mta:Moth_0027 DNA polymerase III, subunits gamma and tau; PFAM: AAA ATPase central domain protein; PRIAM: DNA-directed DNA polymerase; SMART: AAA ATPase; SPTR: DNA polymerase III, gamma and tau subunit; TIGRFAM: DNA polymerase III, subunits gamma and tau; PFAM: ATPase family associated with various cellular activities (AAA); DNA polymerase III subunits gamma and tau domain III; TIGRFAM: DNA polymerase III, delta' subunit; DNA polymerase III, subunit gamma and tau.
   
 0.990
Tmar_2194
COGs: COG1466 DNA polymerase III delta subunit; InterPro IPR010372: IPR005790; KEGG: pth:PTH_0867 DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; SPTR: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit.
   
 0.990
Tmar_0080
Hypothetical protein; COGs: COG2812 DNA polymerase III gamma/tau subunits; KEGG: saq:Sare_4403 DNA polymerase III, delta prime subunit; SPTR: DNA polymerase III, delta prime subunit; TIGRFAM: DNA polymerase III, delta' subunit.
   
 0.986
Tmar_0370
DNA polymerase III catalytic subunit, DnaE type; COGs: COG0587 DNA polymerase III alpha subunit; InterPro IPR006162: IPR003141: IPR004805: IPR004013: IPR 011708: IPR004365; KEGG: hmo:HM1_0084 DNA polymerase III alpha subunit, putative; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; PRIAM: DNA-directed DNA polymerase; SMART: phosphoesterase PHP domain protein; SPTR: DNA polymerase iii alpha subunit, putative; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: PHP domain; Bacterial DNA polymerase III alpha subunit; OB-fold nucl [...]
    
 0.986
Tmar_0130
3'-5' exonuclease, PolB; InterPro IPR019288; KEGG: hoh:Hoch_5692 3'-5' exonuclease, PolB-like protein; PFAM: 3'-5' exonuclease, PolB-like; SPTR: Putative uncharacterized protein; PFAM: Predicted 3'-5' exonuclease related to the exonuclease domain of PolB.
  
 0.983
Tmar_1128
DNA polymerase LigD, ligase domain protein; COGs: COG1793 ATP-dependent DNA ligase; InterPro IPR014146: IPR012310: IPR012309; KEGG: afw:Anae109_0939 DNA ligase D; PFAM: ATP dependent DNA ligase; ATP dependent DNA ligase domain protein; SPTR: DNA ligase D; TIGRFAM: DNA polymerase LigD, ligase domain protein; PFAM: ATP dependent DNA ligase domain; ATP dependent DNA ligase C terminal region; TIGRFAM: DNA polymerase LigD, ligase domain.
   
 0.982
mutS
DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.
   
 0.979
Tmar_0798
KEGG: acp:A2cp1_2337 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: impB/mucB/samB family.
   
 0.966
Your Current Organism:
Thermaerobacter marianensis
NCBI taxonomy Id: 644966
Other names: T. marianensis DSM 12885, Thermaerobacter marianensis 7p75a, Thermaerobacter marianensis ATCC 700841, Thermaerobacter marianensis DSM 12885, Thermaerobacter marianensis str. DSM 12885, Thermaerobacter marianensis strain DSM 12885
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