STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tmar_0005KEGG: sth:STH5 hypothetical protein; SPTR: Putative uncharacterized protein. (151 aa)    
Predicted Functional Partners:
Tmar_0004
Protein of unknown function DUF721; InterPro IPR007922; KEGG: cya:CYA_2562 hypothetical protein; PFAM: protein of unknown function DUF721; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF721).
       0.710
recF
DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family.
  
    0.633
Tmar_0452
KEGG: sth:STH1605 hypothetical protein; SPTR: ATPase.
  
     0.557
Tmar_1130
Sporulation protein YtfJ; COGs: COG3874 conserved hypothetical protein; InterPro IPR014229; KEGG: tjr:TherJR_1631 sporulation protein YtfJ; PFAM: Sporulation protein YtfJ; SPTR: Sporulation protein YtfJ; TIGRFAM: sporulation protein YtfJ; PFAM: Sporulation protein YtfJ (Spore_YtfJ); TIGRFAM: sporulation protein YtfJ.
  
     0.497
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
  
    0.466
Tmar_0002
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
    0.462
Tmar_0224
KEGG: slp:Slip_1767 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: HutP.
  
     0.456
Tmar_1168
KEGG: mta:Moth_1512 hypothetical protein; SPTR: Putative uncharacterized protein.
  
     0.436
Tmar_0913
Protein of unknown function DUF370; COGs: COG2052 conserved hypothetical protein; InterPro IPR007169; KEGG: adg:Adeg_0839 protein of unknown function DUF370; PFAM: protein of unknown function DUF370; SPTR: Putative uncharacterized protein; PFAM: Domain of unknown function (DUF370); Belongs to the RemA family.
  
   
 0.404
Your Current Organism:
Thermaerobacter marianensis
NCBI taxonomy Id: 644966
Other names: T. marianensis DSM 12885, Thermaerobacter marianensis 7p75a, Thermaerobacter marianensis ATCC 700841, Thermaerobacter marianensis DSM 12885, Thermaerobacter marianensis str. DSM 12885, Thermaerobacter marianensis strain DSM 12885
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.