STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tmar_0072COGs: COG2812 DNA polymerase III gamma/tau subunits; InterPro IPR003593: IPR003959: IPR012763: IPR001270; KEGG: mta:Moth_0027 DNA polymerase III, subunits gamma and tau; PFAM: AAA ATPase central domain protein; PRIAM: DNA-directed DNA polymerase; SMART: AAA ATPase; SPTR: DNA polymerase III, gamma and tau subunit; TIGRFAM: DNA polymerase III, subunits gamma and tau; PFAM: ATPase family associated with various cellular activities (AAA); DNA polymerase III subunits gamma and tau domain III; TIGRFAM: DNA polymerase III, delta' subunit; DNA polymerase III, subunit gamma and tau. (825 aa)    
Predicted Functional Partners:
Tmar_0002
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.990
Tmar_2194
COGs: COG1466 DNA polymerase III delta subunit; InterPro IPR010372: IPR005790; KEGG: pth:PTH_0867 DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; SPTR: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit.
 
 
 0.990
Tmar_0370
DNA polymerase III catalytic subunit, DnaE type; COGs: COG0587 DNA polymerase III alpha subunit; InterPro IPR006162: IPR003141: IPR004805: IPR004013: IPR 011708: IPR004365; KEGG: hmo:HM1_0084 DNA polymerase III alpha subunit, putative; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; PRIAM: DNA-directed DNA polymerase; SMART: phosphoesterase PHP domain protein; SPTR: DNA polymerase iii alpha subunit, putative; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: PHP domain; Bacterial DNA polymerase III alpha subunit; OB-fold nucl [...]
 
 0.987
recR
DNA replication and repair protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.
  
 0.940
Tmar_0080
Hypothetical protein; COGs: COG2812 DNA polymerase III gamma/tau subunits; KEGG: saq:Sare_4403 DNA polymerase III, delta prime subunit; SPTR: DNA polymerase III, delta prime subunit; TIGRFAM: DNA polymerase III, delta' subunit.
 
  
0.933
Tmar_0073
Uncharacterized protein family UPF0133; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
  
  
 0.891
Tmar_0800
COGs: COG0587 DNA polymerase III alpha subunit; InterPro IPR004013: IPR011708: IPR004365: IPR004805: IPR 003141; KEGG: sth:STH1885 DNA polymerase III alpha subunit; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; PRIAM: DNA-directed DNA polymerase; SMART: phosphoesterase PHP domain protein; SPTR: Error-prone DNA polymerase; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: Bacterial DNA polymerase III alpha subunit; PHP domain; TIGRFAM: DNA-directed DNA polymerase III (polc).
 
 
 0.885
Tmar_2354
Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
   
 
 0.875
Tmar_2350
Primary replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily.
 
 
 
 0.723
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
   
 0.550
Your Current Organism:
Thermaerobacter marianensis
NCBI taxonomy Id: 644966
Other names: T. marianensis DSM 12885, Thermaerobacter marianensis 7p75a, Thermaerobacter marianensis ATCC 700841, Thermaerobacter marianensis DSM 12885, Thermaerobacter marianensis str. DSM 12885, Thermaerobacter marianensis strain DSM 12885
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.