STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tmar_0305Phosphodiesterase, MJ0936 family protein; COGs: COG0622 phosphoesterase; InterPro IPR000979: IPR004843; KEGG: dau:Daud_0456 phosphodiesterase; PFAM: metallophosphoesterase; SPTR: Phosphodiesterase, MJ0936 family; TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: Calcineurin-like phosphoesterase; TIGRFAM: phosphoesterase, MJ0936 family. (171 aa)    
Predicted Functional Partners:
Tmar_2231
Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
  
 0.833
Tmar_2229
Ankyrin; COGs: COG0666 FOG: Ankyrin repeat; InterPro IPR002110: IPR020683; KEGG: tpe:Tpen_1284 ankyrin; PFAM: Ankyrin; SMART: Ankyrin; SPTR: Ankyrin; PFAM: Ankyrin repeat.
    
 
 0.830
Tmar_0306
Extracellular solute-binding protein family 5; COGs: COG0747 ABC-type dipeptide transport system periplasmic component; InterPro IPR000914; KEGG: pca:Pcar_1870 dipeptide transport protein; PFAM: extracellular solute-binding protein family 5; SPTR: Dipeptide transport protein; PFAM: Bacterial extracellular solute-binding proteins, family 5 Middle.
       0.689
Tmar_0304
D-amino acid aminotransferase; Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha-keto acid in the first half-reaction.
       0.465
Tmar_0303
Geranylgeranylglyceryl phosphate synthase family protein; COGs: COG1646 phosphate-binding protein with TIM-barrel fold; InterPro IPR008205; KEGG: sth:STH150 geranylgeranylglyceryl phosphate synthase-like protein; PFAM: PcrB family protein; PRIAM: Phosphoglycerol geranylgeranyltransferase; SPTR: Putative uncharacterized protein; TIGRFAM: geranylgeranylglyceryl phosphate synthase family protein; PFAM: PcrB family; TIGRFAM: geranylgeranylglyceryl phosphate synthase family protein.
       0.457
nuoA
NADH dehydrogenase subunit A; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 3 family.
       0.421
nuoB
NADH dehydrogenase subunit B; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
       0.421
Tmar_0396
Esterase; COGs: COG0627 esterase; InterPro IPR000801; KEGG: ttr:Tter_0425 putative esterase; PFAM: esterase; SPTR: Putative esterase; PFAM: Putative esterase.
  
  
 0.419
Your Current Organism:
Thermaerobacter marianensis
NCBI taxonomy Id: 644966
Other names: T. marianensis DSM 12885, Thermaerobacter marianensis 7p75a, Thermaerobacter marianensis ATCC 700841, Thermaerobacter marianensis DSM 12885, Thermaerobacter marianensis str. DSM 12885, Thermaerobacter marianensis strain DSM 12885
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