STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pepALeucyl aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. (579 aa)    
Predicted Functional Partners:
Tmar_1467
COGs: COG0405 Gamma-glutamyltransferase; InterPro IPR000101; KEGG: sti:Sthe_0854 gamma-glutamyltransferase; PFAM: gamma-glutamyltranspeptidase; PRIAM: Gamma-glutamyltransferase; SPTR: Gamma-glutamyltransferase; TIGRFAM: gamma-glutamyltransferase; PFAM: Gamma-glutamyltranspeptidase; TIGRFAM: gamma-glutamyltranspeptidase.
     
 0.916
Tmar_0844
COGs: COG0031 Cysteine synthase; InterPro IPR001926: IPR005856: IPR005859: IPR001216; KEGG: mta:Moth_1706 cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: Cysteine synthase; TIGRFAM: cysteine synthase A; cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; Belongs to the cysteine synthase/cystathionine beta- synthase family.
   
 0.836
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.832
Tmar_0353
L-aspartate aminotransferase apoenzyme; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR001176: IPR004838: IPR004839; KEGG: adg:Adeg_1380 aminotransferase class I and II; PFAM: aminotransferase class I and II; SPTR: Aminotransferase class I and II; PFAM: Aminotransferase class I and II.
   
  0.819
Tmar_1070
PHP domain protein; COGs: COG0613 metal-dependent phosphoesterase (PHP family); InterPro IPR003141: IPR004013; KEGG: dae:Dtox_3096 PHP domain protein; PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; SPTR: PHP domain protein; PFAM: PHP domain.
       0.786
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
 
 
  0.580
Tmar_1068
Dipeptidase; COGs: COG2355 Zn-dependent dipeptidase microsomal dipeptidase homolog; InterPro IPR008257; KEGG: dae:Dtox_3097 membrane dipeptidase; PFAM: peptidase M19 renal dipeptidase; PRIAM: Membrane dipeptidase; SPTR: Membrane dipeptidase; PFAM: Membrane dipeptidase (Peptidase family M19).
       0.478
Tmar_1071
KEGG: sth:STH1772 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.432
Tmar_1626
COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: tro:trd_1049 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; PFAM: methylenetetrahydrofolate reductase; SPTR: Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Homocysteine S-methyltransferase.
     
 0.404
Your Current Organism:
Thermaerobacter marianensis
NCBI taxonomy Id: 644966
Other names: T. marianensis DSM 12885, Thermaerobacter marianensis 7p75a, Thermaerobacter marianensis ATCC 700841, Thermaerobacter marianensis DSM 12885, Thermaerobacter marianensis str. DSM 12885, Thermaerobacter marianensis strain DSM 12885
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.