STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tmar_1093Helicase c2; COGs: COG1199 Rad3-related DNA helicase; InterPro IPR006555: IPR014013; KEGG: sth:STH1713 ATP-dependent DNA helicase; SMART: helicase c2; SPTR: ATP-dependent DNA helicase; PFAM: Type III restriction enzyme, res subunit. (805 aa)    
Predicted Functional Partners:
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
   
 0.976
rpoZ
DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
    
 0.967
rpoB
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 0.966
Tmar_0782
Metallophosphoesterase; COGs: COG0420 DNA repair exonuclease; InterPro IPR004843; KEGG: sth:STH2307 putative phosphoesterase; PFAM: metallophosphoesterase; SPTR: Putative phosphoesterase; PFAM: Calcineurin-like phosphoesterase.
   
 0.957
Tmar_0443
Sigma-70 region 4 domain protein; InterPro IPR011260: IPR007630; KEGG: ttr:Tter_0596 sigma-70 region 4 domain protein; PFAM: sigma-70 region 4 domain protein; RNA polymerase alpha subunit domain protein; SPTR: RNA polymerase sigma factor; PFAM: Bacterial RNA polymerase, alpha chain C terminal domain.
    
 0.956
rpoA
DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 0.956
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 0.846
Tmar_0130
3'-5' exonuclease, PolB; InterPro IPR019288; KEGG: hoh:Hoch_5692 3'-5' exonuclease, PolB-like protein; PFAM: 3'-5' exonuclease, PolB-like; SPTR: Putative uncharacterized protein; PFAM: Predicted 3'-5' exonuclease related to the exonuclease domain of PolB.
  
 0.827
Tmar_1576
SNF2-related protein; COGs: COG0553 Superfamily II DNA/RNA helicase SNF2 family; InterPro IPR007527: IPR014021: IPR001650: IPR014001: IPR 000330; KEGG: dma:DMR_35980 putative helicase; PFAM: SNF2-related protein; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein; SPTR: Putative helicase; PFAM: Helicase conserved C-terminal domain; SNF2 family N-terminal domain; Bacterial SNF2 helicase associated; SWIM zinc finger.
  
 
 0.821
Tmar_0002
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.815
Your Current Organism:
Thermaerobacter marianensis
NCBI taxonomy Id: 644966
Other names: T. marianensis DSM 12885, Thermaerobacter marianensis 7p75a, Thermaerobacter marianensis ATCC 700841, Thermaerobacter marianensis DSM 12885, Thermaerobacter marianensis str. DSM 12885, Thermaerobacter marianensis strain DSM 12885
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.