STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tmar_1483COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873; KEGG: sti:Sthe_2025 AMP-dependent synthetase and ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: AMP-dependent synthetase and ligase; PFAM: Domain of unknown function (DUF3448); AMP-binding enzyme. (653 aa)    
Predicted Functional Partners:
Tmar_1299
COGs: COG0372 Citrate synthase; InterPro IPR019810: IPR002020: IPR011278; KEGG: bts:Btus_2368 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase; PRIAM: Citrate (Si)-synthase; SPTR: 2-methylcitrate synthase/citrate synthase II; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; Belongs to the citrate synthase family.
  
 0.949
Tmar_2000
COGs: COG0372 Citrate synthase; InterPro IPR002020: IPR019810; KEGG: aac:Aaci_0798 citrate synthase 3; PFAM: Citrate synthase; PRIAM: 2-methylcitrate synthase; SPTR: Citrate (Si)-synthase; PFAM: Citrate synthase; Belongs to the citrate synthase family.
  
 0.949
Tmar_1398
COGs: COG2225 Malate synthase; InterPro IPR019830: IPR006252: IPR011076; KEGG: tro:trd_0495 malate synthase; PFAM: Malate synthase family protein; PRIAM: Malate synthase; SPTR: Malate synthase; TIGRFAM: malate synthase A; PFAM: Malate synthase; TIGRFAM: malate synthase A; Belongs to the malate synthase family.
   
 0.945
Tmar_0274
COGs: COG0183 Acetyl-CoA acetyltransferase; InterPro IPR020616: IPR020617: IPR002155: IPR020615: IPR 020610: IPR020613; KEGG: bts:Btus_3277 acetyl-CoA acetyltransferase; PFAM: Thiolase-like; PRIAM: Acetyl-CoA C-acetyltransferase; SPTR: Acetyl-CoA acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase, C-terminal domain; Thiolase, N-terminal domain; TIGRFAM: acetyl-CoA acetyltransferases; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.927
Tmar_0901
CoA-binding domain protein; COGs: COG1042 Acyl-CoA synthetase (NDP forming); InterPro IPR011761: IPR000182: IPR003781: IPR013650; KEGG: bts:Btus_1136 CoA-binding domain protein; PFAM: CoA-binding domain protein; GCN5-related N-acetyltransferase; ATP-grasp domain protein; SPTR: CoA-binding domain protein; PFAM: CoA binding domain; Acetyltransferase (GNAT) family; TIGRFAM: acetyl coenzyme A synthetase (ADP forming), alpha domain.
    
 0.927
Tmar_1368
Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR017441: IPR019752: IPR002880; KEGG: bbe:BBR47_33900 2-oxo acid oxidoreductase alpha subunit; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; SPTR: 2-oxo acid oxidoreductase alpha subunit; PFAM: domain; Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, alpha subunit.
  
 
 0.922
Tmar_1433
Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR019752: IPR002880; KEGG: gwc:GWCH70_1195 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; SPTR: Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: domain; Pyruvate ferredoxin/flavodoxin oxidoreductase; Transketolase, C-terminal domain; TIGRFAM: 2-ox [...]
  
 
 0.922
Tmar_1485
Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR019752: IPR002880; KEGG: mbu:Mbur_0890 pyruvate flavodoxin/ferredoxin oxidoreductase-like protein; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; SPTR: Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: domain; Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, alpha s [...]
  
 
 0.922
Tmar_1671
Catalytic domain-containing protein of components of various dehydrogenase complexes; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR000089: IPR003016: IPR004167: IPR001078; KEGG: sth:STH413 pyruvate dehydrogenase E2; PFAM: catalytic domain-containing protein of components of various dehydrogenase complexes; biotin/lipoyl attachment domain-containing protein; E3 binding domain protein; SPTR: Pyruvate dehydrogenase E2; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); e3 binding domain; Biotin-requi [...]
  
 
 0.912
Tmar_2260
Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
  
 0.912
Your Current Organism:
Thermaerobacter marianensis
NCBI taxonomy Id: 644966
Other names: T. marianensis DSM 12885, Thermaerobacter marianensis 7p75a, Thermaerobacter marianensis ATCC 700841, Thermaerobacter marianensis DSM 12885, Thermaerobacter marianensis str. DSM 12885, Thermaerobacter marianensis strain DSM 12885
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.