STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tmar_2195DNA internalization-related competence protein ComEC/Rec2; COGs: COG2333 hydrolase (metallo-beta-lactamase superfamily); InterPro IPR004477: IPR000408: IPR004797; KEGG: sth:STH473 ComE-like competence protein; PFAM: ComEC/Rec2-related protein; SPTR: ComE-like competence protein; TIGRFAM: DNA internalization-related competence protein ComEC/Rec2; ComEC/Rec2-related protein; PFAM: Competence protein; Metallo-beta-lactamase superfamily; TIGRFAM: ComEC/Rec2-related protein; DNA internalization-related competence protein ComEC/Rec2. (969 aa)    
Predicted Functional Partners:
Tmar_0969
DNA protecting protein DprA; COGs: COG0758 Rossmann fold nucleotide-binding protein involved in DNA uptake; InterPro IPR003488; KEGG: mta:Moth_1025 DNA processing protein DprA, putative; PFAM: SMF family protein; SPTR: DNA processing protein DprA, putative; TIGRFAM: DNA protecting protein DprA; PFAM: DNA recombination-mediator protein A; TIGRFAM: DNA protecting protein DprA.
 
  
 0.897
Tmar_2196
Competence protein ComEA helix-hairpin-helix repeat protein; COGs: COG1555 DNA uptake protein and related DNA-binding protein; InterPro IPR003583: IPR019554: IPR004509; KEGG: sth:STH455 putative DNA-binding protein; PFAM: Soluble ligand binding domain; SMART: Helix-hairpin-helix DNA-binding class 1; SPTR: Putative DNA-binding protein; TIGRFAM: competence protein ComEA helix-hairpin-helix repeat protein; PFAM: SLBB domain; Helix-hairpin-helix motif; TIGRFAM: competence protein ComEA helix-hairpin-helix repeat region; comEA protein.
 
  
 0.892
Tmar_0191
COGs: COG1040 amidophosphoribosyltransferase; InterPro IPR000836; KEGG: dds:Ddes_1733 ComF family protein; PFAM: phosphoribosyltransferase; SPTR: ComF family protein; PFAM: Phosphoribosyl transferase domain; TIGRFAM: comF family protein.
 
  
 0.877
Tmar_0665
COGs: COG1459 Type II secretory pathway component PulF; InterPro IPR018076: IPR003004: IPR001992; KEGG: dau:Daud_0970 type II secretion system protein; PFAM: Type II secretion system F domain; SPTR: Type II secretion system protein; PFAM: Bacterial type II secretion system protein F domain.
  
  
 0.795
Tmar_0663
Prepilin peptidase; COGs: COG1989 Type II secretory pathway prepilin signal peptidase PulO and related peptidase; InterPro IPR010627: IPR000045: IPR000530; KEGG: rxy:Rxyl_1154 peptidase A24A-like protein; PFAM: peptidase A24A domain protein; peptidase A24A prepilin type IV; PRIAM: Prepilin peptidase; SPTR: Peptidase A24A-like protein; PFAM: Bacterial Peptidase A24 N-terminal domain; Type IV leader peptidase family.
  
  
 0.785
Tmar_2194
COGs: COG1466 DNA polymerase III delta subunit; InterPro IPR010372: IPR005790; KEGG: pth:PTH_0867 DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; SPTR: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit.
 
   
 0.774
Tmar_0664
COGs: COG2804 Type II secretory pathway ATPase PulE/Tfp pilus assembly pathway ATPase PilB; InterPro IPR007831: IPR001482: IPR003593; KEGG: dtu:Dtur_0873 general secretory pathway protein E; PFAM: type II secretion system protein E; General secretory system II protein E domain protein; SMART: AAA ATPase; SPTR: General secretory pathway protein E; PFAM: GSPII_E N-terminal domain; Type II/IV secretion system protein; TIGRFAM: pilus retraction protein PilT.
  
  
 0.724
Tmar_0284
COGs: COG0642 Signal transduction histidine kinase; InterPro IPR003661: IPR003594: IPR006674: IPR003018: IPR 013656: IPR000014: IPR005467: IPR000700: IPR004358; KEGG: bts:Btus_0284 signal transduction histidine kinase, nitrogen specific, NtrB; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; GAF domain protein; metal-dependent phosphohydrolase HD sub domain; PAS fold-4 domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SPTR: Signal transduction histidine kinase, nitrogen specific, NtrB; TIGRFAM: PAS sens [...]
  
    0.643
Tmar_1041
Cell division protein FtsK/SpoIIIE; COGs: COG1674 DNA segregation ATPase FtsK/SpoIIIE and related protein; InterPro IPR003593: IPR002543: IPR018541; KEGG: sth:STH1561 stage III sporulation protein E; PFAM: cell divisionFtsK/SpoIIIE; DNA translocase ftsK gamma; SMART: AAA ATPase; SPTR: Stage III sporulation protein E; PFAM: Ftsk gamma domain; FtsK/SpoIIIE family.
 
  
 0.642
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
  
 0.641
Your Current Organism:
Thermaerobacter marianensis
NCBI taxonomy Id: 644966
Other names: T. marianensis DSM 12885, Thermaerobacter marianensis 7p75a, Thermaerobacter marianensis ATCC 700841, Thermaerobacter marianensis DSM 12885, Thermaerobacter marianensis str. DSM 12885, Thermaerobacter marianensis strain DSM 12885
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